8DPS

The structure of the interleukin 11 signalling complex, truncated gp130

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Interleukin-6 receptor subunit beta	polymer	303	34564.0	2	UniProt (P40189) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041) In PDB	Homo sapiens (human)	IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha
2	B, E	Interleukin-11	polymer	169	18273.3	2	UniProt (P20809) Pfam (PF07400) In PDB	Homo sapiens (human)	IL-11,Adipogenesis inhibitory factor,AGIF
3	C, F	Interleukin-11 receptor subunit alpha	polymer	298	32208.0	2	UniProt (Q14626) In PDB	Homo sapiens (human)	IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha,IL-11RA
4	G, I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	H, J	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6	A, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

B, E: 11 - 178 (UniProt: P20809)

PDB	External Database	Details
Gly 10	-	expression tag

C, F: 1 - 297 (UniProt: Q14626)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 226	Cys 248	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	170090.5
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	172997.2

*Water molecules are not included.