8DPS

The structure of the interleukin 11 signalling complex, truncated gp130

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005125	molecular_function	cytokine activity
B	0005142	molecular_function	interleukin-11 receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0008083	molecular_function	growth factor activity
B	0008283	biological_process	cell population proliferation
B	0008284	biological_process	positive regulation of cell population proliferation
B	0030183	biological_process	B cell differentiation
B	0030219	biological_process	megakaryocyte differentiation
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0038154	biological_process	interleukin-11-mediated signaling pathway
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045444	biological_process	fat cell differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046888	biological_process	negative regulation of hormone secretion
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	1903659	biological_process	regulation of complement-dependent cytotoxicity
B	2000352	biological_process	negative regulation of endothelial cell apoptotic process
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
E	0005125	molecular_function	cytokine activity
E	0005142	molecular_function	interleukin-11 receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0008083	molecular_function	growth factor activity
E	0008283	biological_process	cell population proliferation
E	0008284	biological_process	positive regulation of cell population proliferation
E	0030183	biological_process	B cell differentiation
E	0030219	biological_process	megakaryocyte differentiation
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0038154	biological_process	interleukin-11-mediated signaling pathway
E	0043410	biological_process	positive regulation of MAPK cascade
E	0045444	biological_process	fat cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046888	biological_process	negative regulation of hormone secretion
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	1903659	biological_process	regulation of complement-dependent cytotoxicity
E	2000352	biological_process	negative regulation of endothelial cell apoptotic process
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LrPDPPqgLrvesvpgyprrLrasWtyPaSWpsqph.FlLkFrL

Chain	Residue	Details
C	LEU194-LEU236

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN105
C	ASN172
F	ASN105
F	ASN172

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061

Chain	Residue	Details
A	ASN109
A	ASN135
D	ASN109
D	ASN135

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20489211

Chain	Residue	Details
A	ASN205
D	ASN205

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