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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7EWR

Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1E, CRegulator of G-protein signaling 7polymer53061570.12UniProt (P49802)
Pfam (PF00610)
Pfam (PF18148)
Pfam (PF00631)
Pfam (PF00615)
In PDB		Homo sapiens (Human)RGS7
2F, DGuanine nucleotide-binding protein subunit beta-5polymer39543619.32UniProt (O14775)
Pfam (PF00400)
In PDB		Homo sapiens (Human)Gbeta5,Transducin beta chain 5
3A, BProbable G-protein coupled receptor 158polymer1138127547.12UniProt (Q5T848)
Pfam (PF00003)
In PDB		Homo sapiens (Human)
Sequence modifications
E, C: 1 - 495 (UniProt: P49802)
PDBExternal DatabaseDetails
Arg 496-expression tag
Gly 497-expression tag
Arg 498-expression tag
Gly 499-expression tag
Gly 500-expression tag
Ser 501-expression tag
Glu 502-expression tag
Asn 503-expression tag
Leu 504-expression tag
Tyr 505-expression tag
Phe 506-expression tag
Gln 507-expression tag
Gly 508-expression tag
Gly 509-expression tag
Ser 510-expression tag
Gly 511-expression tag
Ser 512-expression tag
Gly 513-expression tag
Gly 514-expression tag
Asp 515-expression tag
Tyr 516-expression tag
Lys 517-expression tag
Asp 518-expression tag
Asp 519-expression tag
Asp 520-expression tag
Asp 521-expression tag
Lys 522-expression tag
Asp 523-expression tag
Tyr 524-expression tag
Lys 525-expression tag
Asp 526-expression tag
Asp 527-expression tag
Asp 528-expression tag
Asp 529-expression tag
Lys 530-expression tag
A, B: 1 - 863 (UniProt: Q5T848)
PDBExternal DatabaseDetails
Arg 864-expression tag
Gly 865-expression tag
Arg 866-expression tag
Leu 867-expression tag
Glu 868-expression tag
Val 869-expression tag
Leu 870-expression tag
Phe 871-expression tag
Gln 872-expression tag
Gly 873-expression tag
Pro 874-expression tag
Gly 875-expression tag
Gly 876-expression tag
Ser 877-expression tag
Met 878-expression tag
Ser 879-expression tag
Lys 880-expression tag
Gly 881-expression tag
Glu 882-expression tag
Glu 883-expression tag
Leu 884-expression tag
Phe 885-expression tag
Thr 886-expression tag
Gly 887-expression tag
Val 888-expression tag
Val 889-expression tag
Pro 890-expression tag
Ile 891-expression tag
Leu 892-expression tag
Val 893-expression tag
Glu 894-expression tag
Leu 895-expression tag
Asp 896-expression tag
Gly 897-expression tag
Asp 898-expression tag
Val 899-expression tag
Asn 900-expression tag
Gly 901-expression tag
His 902-expression tag
Lys 903-expression tag
Phe 904-expression tag
Ser 905-expression tag
Val 906-expression tag
Arg 907-expression tag
Gly 908-expression tag
Glu 909-expression tag
Gly 910-expression tag
Glu 911-expression tag
Gly 912-expression tag
Asp 913-expression tag
Ala 914-expression tag
Thr 915-expression tag
Asn 916-expression tag
Gly 917-expression tag
Lys 918-expression tag
Leu 919-expression tag
Thr 920-expression tag
Leu 921-expression tag
Lys 922-expression tag
Phe 923-expression tag
Ile 924-expression tag
Cys 925-expression tag
Thr 926-expression tag
Thr 927-expression tag
Gly 928-expression tag
Lys 929-expression tag
Leu 930-expression tag
Pro 931-expression tag
Val 932-expression tag
Pro 933-expression tag
Trp 934-expression tag
Pro 935-expression tag
Thr 936-expression tag
Leu 937-expression tag
Val 938-expression tag
Thr 939-expression tag
Thr 940-expression tag
Leu 941-expression tag
Thr 942-expression tag
Tyr 943-expression tag
Gly 944-expression tag
Val 945-expression tag
Gln 946-expression tag
Cys 947-expression tag
Phe 948-expression tag
Ser 949-expression tag
Arg 950-expression tag
Tyr 951-expression tag
Pro 952-expression tag
Asp 953-expression tag
His 954-expression tag
Met 955-expression tag
Lys 956-expression tag
Arg 957-expression tag
His 958-expression tag
Asp 959-expression tag
Phe 960-expression tag
Phe 961-expression tag
Lys 962-expression tag
Ser 963-expression tag
Ala 964-expression tag
Met 965-expression tag
Pro 966-expression tag
Glu 967-expression tag
Gly 968-expression tag
Tyr 969-expression tag
Val 970-expression tag
Gln 971-expression tag
Glu 972-expression tag
Arg 973-expression tag
Thr 974-expression tag
Ile 975-expression tag
Ser 976-expression tag
Phe 977-expression tag
Lys 978-expression tag
Asp 979-expression tag
Asp 980-expression tag
Gly 981-expression tag
Thr 982-expression tag
Tyr 983-expression tag
Lys 984-expression tag
Thr 985-expression tag
Arg 986-expression tag
Ala 987-expression tag
Glu 988-expression tag
Val 989-expression tag
Lys 990-expression tag
Phe 991-expression tag
Glu 992-expression tag
Gly 993-expression tag
Asp 994-expression tag
Thr 995-expression tag
Leu 996-expression tag
Val 997-expression tag
Asn 998-expression tag
Arg 999-expression tag
Ile 1000-expression tag
Glu 1001-expression tag
Leu 1002-expression tag
Lys 1003-expression tag
Gly 1004-expression tag
Ile 1005-expression tag
Asp 1006-expression tag
Phe 1007-expression tag
Lys 1008-expression tag
Glu 1009-expression tag
Asp 1010-expression tag
Gly 1011-expression tag
Asn 1012-expression tag
Ile 1013-expression tag
Leu 1014-expression tag
Gly 1015-expression tag
His 1016-expression tag
Lys 1017-expression tag
Leu 1018-expression tag
Glu 1019-expression tag
Tyr 1020-expression tag
Asn 1021-expression tag
Phe 1022-expression tag
Asn 1023-expression tag
Ser 1024-expression tag
His 1025-expression tag
Asn 1026-expression tag
Val 1027-expression tag
Tyr 1028-expression tag
Ile 1029-expression tag
Thr 1030-expression tag
Ala 1031-expression tag
Asp 1032-expression tag
Lys 1033-expression tag
Gln 1034-expression tag
Lys 1035-expression tag
Asn 1036-expression tag
Gly 1037-expression tag
Ile 1038-expression tag
Lys 1039-expression tag
Ala 1040-expression tag
Asn 1041-expression tag
Phe 1042-expression tag
Lys 1043-expression tag
Ile 1044-expression tag
Arg 1045-expression tag
His 1046-expression tag
Asn 1047-expression tag
Val 1048-expression tag
Glu 1049-expression tag
Asp 1050-expression tag
Gly 1051-expression tag
Ser 1052-expression tag
Val 1053-expression tag
Gln 1054-expression tag
Leu 1055-expression tag
Ala 1056-expression tag
Asp 1057-expression tag
His 1058-expression tag
Tyr 1059-expression tag
Gln 1060-expression tag
Gln 1061-expression tag
Asn 1062-expression tag
Thr 1063-expression tag
Pro 1064-expression tag
Ile 1065-expression tag
Gly 1066-expression tag
Asp 1067-expression tag
Gly 1068-expression tag
Pro 1069-expression tag
Val 1070-expression tag
Leu 1071-expression tag
Leu 1072-expression tag
Pro 1073-expression tag
Asp 1074-expression tag
Asn 1075-expression tag
His 1076-expression tag
Tyr 1077-expression tag
Leu 1078-expression tag
Ser 1079-expression tag
Thr 1080-expression tag
Gln 1081-expression tag
Ser 1082-expression tag
Val 1083-expression tag
Leu 1084-expression tag
Ser 1085-expression tag
Lys 1086-expression tag
Asp 1087-expression tag
Pro 1088-expression tag
Asn 1089-expression tag
Glu 1090-expression tag
Lys 1091-expression tag
Arg 1092-expression tag
Asp 1093-expression tag
His 1094-expression tag
Met 1095-expression tag
Val 1096-expression tag
Leu 1097-expression tag
Leu 1098-expression tag
Glu 1099-expression tag
Phe 1100-expression tag
Val 1101-expression tag
Thr 1102-expression tag
Ala 1103-expression tag
Ala 1104-expression tag
Gly 1105-expression tag
Ile 1106-expression tag
Thr 1107-expression tag
His 1108-expression tag
Gly 1109-expression tag
Gly 1110-expression tag
Ser 1111-expression tag
Trp 1112-expression tag
Ser 1113-expression tag
His 1114-expression tag
Pro 1115-expression tag
Gln 1116-expression tag
Phe 1117-expression tag
Glu 1118-expression tag
Lys 1119-expression tag
Gly 1120-expression tag
Gly 1121-expression tag
Gly 1122-expression tag
Ser 1123-expression tag
Gly 1124-expression tag
Gly 1125-expression tag
Gly 1126-expression tag
Ser 1127-expression tag
Gly 1128-expression tag
Gly 1129-expression tag
Ser 1130-expression tag
Ala 1131-expression tag
Trp 1132-expression tag
Ser 1133-expression tag
His 1134-expression tag
Pro 1135-expression tag
Gln 1136-expression tag
Phe 1137-expression tag
Glu 1138-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight465473.0
All*Total formula weight465473.0
*Water molecules are not included.

220472

PDB entries from 2024-05-29

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