6XWG

Crystal Structure of the Human RXR/RAR DNA-Binding Domain Heterodimer Bound to the Human RARb2 DR5 Response Element

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RARb2 DR5 Response Element, 5'-3' strand	polymer	21	6447.2	1		Homo sapiens
2	B	RARb2 DR5 Response Element, 3'-5' strand	polymer	21	6438.2	1		Homo sapiens
3	C	Retinoic acid receptor RXR-alpha	polymer	87	10262.9	1	UniProt (P19793) Pfam (PF00105) In PDB	Homo sapiens (Human)	Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha
4	D	Retinoic acid receptor alpha	polymer	90	10633.5	1	UniProt (P10276) Pfam (PF00105) In PDB	Homo sapiens (Human)	RAR-alpha,Nuclear receptor subfamily 1 group B member 1
5	C, D	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	C	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7	C	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8		water	water		18.0	36	Chemie (HOH)

Sequence modifications

C: 130 - 212 (UniProt: P19793)

PDB	External Database	Details
Gly 126	-	expression tag
Ser 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag

D: 82 - 167 (UniProt: P10276)

PDB	External Database	Details
Gly 78	-	expression tag
Ser 79	-	expression tag
His 80	-	expression tag
Met 81	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	33781.8
Non-Polymers*	Number of molecules	6
	Total formula weight	389.2
All*	Total formula weight	34170.9

*Water molecules are not included.