6XWG

Crystal Structure of the Human RXR/RAR DNA-Binding Domain Heterodimer Bound to the Human RARb2 DR5 Response Element

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	CYS135
C	CYS138
C	CYS152
C	CYS155

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
C	CYS171
C	CYS177
C	CYS187
C	CYS190

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site_id	AC3
Number of Residues	3
Details	binding site for residue GOL C 303

Chain	Residue
C	TYR150
D	LYS147
C	LYS145

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL C 304

Chain	Residue
C	ARG202
C	GLU203

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site_id	AC5
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	CYS88
D	CYS91
D	CYS105
D	CYS108

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site_id	AC6
Number of Residues	4
Details	binding site for residue ZN D 302

Chain	Residue
D	CYS124
D	CYS130
D	CYS140
D	CYS143

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Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR

Chain	Residue	Details
D	CYS88-ARG114
C	CYS135-ARG161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
D	CYS88-MET153
C	LEU167

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site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
D	CYS88-CYS108
D	CYS124-CYS148

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKB/AKT1 => ECO:0000269|PubMed:16417524

Chain	Residue	Details
D	SER96

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:19850744

Chain	Residue	Details
D	LYS166

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