6UMX
Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Growth/differentiation factor 8 | polymer | 365 | 41642.3 | 2 | UniProt (O14793) Pfam (PF00688) Pfam (PF00019) In PDB | Homo sapiens (Human) | GDF-8, Myostatin |
2 | L, l | GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain | polymer | 215 | 22655.9 | 2 | UniProt (P0DOY2) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | H, h | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain | polymer | 229 | 24725.9 | 2 | UniProt (Q5EFE5) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
4 | h | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 375 (UniProt: O14793)
L, l: 1 - 110 (PDB: 6UMX)
L, l: 111 - 215 (UniProt: P0DOY2)
H, h: 1 - 121 (PDB: 6UMX)
H, h: 122 - 229 (UniProt: Q5EFE5)
PDB | External Database | Details |
---|---|---|
His 11 | - | expression tag |
His 12 | - | expression tag |
His 13 | - | expression tag |
His 14 | - | expression tag |
His 15 | - | expression tag |
His 16 | - | expression tag |
Glu 17 | - | expression tag |
Asn 18 | - | expression tag |
Leu 19 | - | expression tag |
Tyr 20 | - | expression tag |
Phe 21 | - | expression tag |
Gln 22 | - | expression tag |
Ser 23 | - | expression tag |
Ala 99 | Asp 99 | engineered mutation |
Ala 263 | Arg 263 | engineered mutation |
Ala 266 | Arg 266 | engineered mutation |
L, l: 111 - 215 (UniProt: P0DOY2)
H, h: 1 - 121 (PDB: 6UMX)
H, h: 122 - 229 (UniProt: Q5EFE5)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 178048.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 92.1 | |
All* | Total formula weight | 178140.3 |