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6UMX

Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015

Functional Information from GO Data
ChainGOidnamespacecontents
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007517biological_processmuscle organ development
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0009629biological_processresponse to gravity
A0010592biological_processpositive regulation of lamellipodium assembly
A0010759biological_processpositive regulation of macrophage chemotaxis
A0014732biological_processskeletal muscle atrophy
A0014741biological_processnegative regulation of muscle hypertrophy
A0014816biological_processskeletal muscle satellite cell differentiation
A0014839biological_processmyoblast migration involved in skeletal muscle regeneration
A0014850biological_processresponse to muscle activity
A0022602biological_processovulation cycle process
A0033574biological_processresponse to testosterone
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043403biological_processskeletal muscle tissue regeneration
A0043627biological_processresponse to estrogen
A0045471biological_processresponse to ethanol
A0045662biological_processnegative regulation of myoblast differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046716biological_processmuscle cell cellular homeostasis
A0048632biological_processnegative regulation of skeletal muscle tissue growth
A0051384biological_processresponse to glucocorticoid
A0051602biological_processresponse to electrical stimulus
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0071456biological_processcellular response to hypoxia
A0071549biological_processcellular response to dexamethasone stimulus
A1902723biological_processnegative regulation of skeletal muscle satellite cell proliferation
A1902725biological_processnegative regulation of satellite cell differentiation
A2000818biological_processnegative regulation of myoblast proliferation
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007517biological_processmuscle organ development
B0008083molecular_functiongrowth factor activity
B0008201molecular_functionheparin binding
B0009629biological_processresponse to gravity
B0010592biological_processpositive regulation of lamellipodium assembly
B0010759biological_processpositive regulation of macrophage chemotaxis
B0014732biological_processskeletal muscle atrophy
B0014741biological_processnegative regulation of muscle hypertrophy
B0014816biological_processskeletal muscle satellite cell differentiation
B0014839biological_processmyoblast migration involved in skeletal muscle regeneration
B0014850biological_processresponse to muscle activity
B0022602biological_processovulation cycle process
B0033574biological_processresponse to testosterone
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043403biological_processskeletal muscle tissue regeneration
B0043627biological_processresponse to estrogen
B0045471biological_processresponse to ethanol
B0045662biological_processnegative regulation of myoblast differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046716biological_processmuscle cell cellular homeostasis
B0048632biological_processnegative regulation of skeletal muscle tissue growth
B0051384biological_processresponse to glucocorticoid
B0051602biological_processresponse to electrical stimulus
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0071456biological_processcellular response to hypoxia
B0071549biological_processcellular response to dexamethasone stimulus
B1902723biological_processnegative regulation of skeletal muscle satellite cell proliferation
B1902725biological_processnegative regulation of satellite cell differentiation
B2000818biological_processnegative regulation of myoblast proliferation
L0002250biological_processadaptive immune response
L0003823molecular_functionantigen binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005886cellular_componentplasma membrane
L0016064biological_processimmunoglobulin mediated immune response
L0019814cellular_componentimmunoglobulin complex
L0070062cellular_componentextracellular exosome
L0071735cellular_componentIgG immunoglobulin complex
L0072562cellular_componentblood microparticle
l0002250biological_processadaptive immune response
l0003823molecular_functionantigen binding
l0005576cellular_componentextracellular region
l0005615cellular_componentextracellular space
l0005886cellular_componentplasma membrane
l0016064biological_processimmunoglobulin mediated immune response
l0019814cellular_componentimmunoglobulin complex
l0070062cellular_componentextracellular exosome
l0071735cellular_componentIgG immunoglobulin complex
l0072562cellular_componentblood microparticle
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue GOL h 301
ChainResidue
HASN84
hARG19
hLYS58
hTHR69

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR207-HIS213
LTYR194-HIS200

site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IiaPkrYkanyCsGeC
ChainResidueDetails
AILE298-CYS313

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage => ECO:0000250|UniProtKB:O08689
ChainResidueDetails
AARG98
BARG98

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN71
BASN71

221051

PDB entries from 2024-06-12

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