6PZK

Cryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the Tetrameric Phosphoprotein (P)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-directed RNA polymerase L	polymer	2201	254482.8	1	UniProt (P28887) Pfam (PF00946) Pfam (PF14318) Pfam (PF14314) In PDB	Human respiratory syncytial virus A2	Protein L,Large structural protein,Replicase,Transcriptase
2	B, C, D, E	Phosphoprotein	polymer	256	29062.9	4	UniProt (P03421) Pfam (PF02478) In PDB	Human respiratory syncytial virus A2	Protein P

Sequence modifications

A: 1 - 2165 (UniProt: P28887)

PDB	External Database	Details
Met -35	-	initiating methionine
Gly -34	-	expression tag
Ser -33	-	expression tag
Trp -32	-	expression tag
Ser -31	-	expression tag
His -30	-	expression tag
Pro -29	-	expression tag
Gln -28	-	expression tag
Phe -27	-	expression tag
Glu -26	-	expression tag
Lys -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Gly -22	-	expression tag
Ser -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
Trp -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
Pro -14	-	expression tag
Gln -13	-	expression tag
Phe -12	-	expression tag
Glu -11	-	expression tag
Lys -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, C, D, E: 1 - 241 (UniProt: P03421)

PDB	External Database	Details
Lys 242	-	expression tag
Gly 243	-	expression tag
Glu 244	-	expression tag
Asn 245	-	expression tag
Lys 246	-	expression tag
Tyr 247	-	expression tag
Phe 248	-	expression tag
Gln 249	-	expression tag
Gly 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
His 256	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	370734.3
All*	Total formula weight	370734.3

*Water molecules are not included.