6PZK

Cryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the Tetrameric Phosphoprotein (P)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001172	biological_process	RNA-templated transcription
A	0003824	molecular_function	catalytic activity
A	0003924	molecular_function	GTPase activity
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0006397	biological_process	mRNA processing
A	0008152	biological_process	metabolic process
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0032259	biological_process	methylation
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0039689	biological_process	negative stranded viral RNA replication
A	0044423	cellular_component	virion component
A	0046872	molecular_function	metal ion binding
A	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
B	0001172	biological_process	RNA-templated transcription
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0019058	biological_process	viral life cycle
B	0030430	cellular_component	host cell cytoplasm
B	0044423	cellular_component	virion component
C	0001172	biological_process	RNA-templated transcription
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0019058	biological_process	viral life cycle
C	0030430	cellular_component	host cell cytoplasm
C	0044423	cellular_component	virion component
D	0001172	biological_process	RNA-templated transcription
D	0003968	molecular_function	RNA-dependent RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0019058	biological_process	viral life cycle
D	0030430	cellular_component	host cell cytoplasm
D	0044423	cellular_component	virion component
E	0001172	biological_process	RNA-templated transcription
E	0003968	molecular_function	RNA-dependent RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0019058	biological_process	viral life cycle
E	0030430	cellular_component	host cell cytoplasm
E	0044423	cellular_component	virion component

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DMNTSDLLCvlEL

Chain	Residue	Details
A	ASP1557-LEU1569

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YGCIVYH

Chain	Residue	Details
A	TYR249-HIS255

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interaction with protein M2-1

Chain	Residue	Details
B	THR108
C	THR108
D	THR108
E	THR108

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by host => ECO:0000269|PubMed:17098979

Chain	Residue	Details
B	THR108
C	THR108
D	THR108
E	THR108

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site_id	SWS_FT_FI3
Number of Residues	20
Details	MOD_RES: Phosphoserine; by host => ECO:0000269|PubMed:12368320, ECO:0000269|PubMed:26474524

Chain	Residue	Details
B	SER116
C	SER237
D	SER116
D	SER117
D	SER119
D	SER232
D	SER237
E	SER116
E	SER117
E	SER119
E	SER232
B	SER117
E	SER237
B	SER119
B	SER232
B	SER237
C	SER116
C	SER117
C	SER119
C	SER232

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:31953395

Chain	Residue	Details
A	ASP811

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q6WB93

Chain	Residue	Details
A	GLY1853

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