6O8B
Crystal structure of STING CTD in complex with TBK1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, E | Stimulator of interferon genes protein | polymer | 226 | 25676.0 | 2 | UniProt (Q86WV6) Pfam (PF15009) In PDB | Homo sapiens (Human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
2 | A, B | Serine/threonine-protein kinase TBK1 | polymer | 665 | 76463.3 | 2 | UniProt (Q9UHD2) Pfam (PF00069) Pfam (PF18396) Pfam (PF18394) In PDB | Homo sapiens (Human) | NF-kappa-B-activating kinase,T2K,TANK-binding kinase 1 |
3 | A, B | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | non-polymer | 591.5 | 2 | Chemie (BX7) |
Sequence modifications
D, E: 155 - 379 (UniProt: Q86WV6)
A, B: 2 - 657 (UniProt: Q9UHD2)
PDB | External Database | Details |
---|---|---|
Ser 154 | - | expression tag |
Arg 232 | His 232 | variant |
Glu 376 | Thr 376 | engineered mutation |
Met 378 | Phe 378 | engineered mutation |
Trp 379 | Ser 379 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -7 | - | expression tag |
Ser -6 | - | expression tag |
Pro -5 | - | expression tag |
Gly -4 | - | expression tag |
Leu -3 | - | expression tag |
Asp -2 | - | expression tag |
Gly -1 | - | expression tag |
Ile 0 | - | expression tag |
Cys 1 | - | expression tag |
Asn 135 | Asp 135 | engineered mutation |
Glu 172 | Ser 172 | engineered mutation |
Asp 388 | Asn 388 | variant |
Gln 570 | Lys 570 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 204278.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1182.9 | |
All* | Total formula weight | 205461.6 |