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6O8B

Crystal structure of STING CTD in complex with TBK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002218biological_processactivation of innate immune response
A0002376biological_processimmune system process
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003676molecular_functionnucleic acid binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0007249biological_processcanonical NF-kappaB signal transduction
A0009615biological_processresponse to virus
A0009967biological_processpositive regulation of signal transduction
A0010468biological_processregulation of gene expression
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016239biological_processpositive regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019903molecular_functionprotein phosphatase binding
A0032479biological_processregulation of type I interferon production
A0032481biological_processpositive regulation of type I interferon production
A0032727biological_processpositive regulation of interferon-alpha production
A0032728biological_processpositive regulation of interferon-beta production
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034142biological_processtoll-like receptor 4 signaling pathway
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043231cellular_componentintracellular membrane-bounded organelle
A0044565biological_processdendritic cell proliferation
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050830biological_processdefense response to Gram-positive bacterium
A0051219molecular_functionphosphoprotein binding
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0106310molecular_functionprotein serine kinase activity
A0140374biological_processantiviral innate immune response
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904417biological_processpositive regulation of xenophagy
B0000166molecular_functionnucleotide binding
B0002218biological_processactivation of innate immune response
B0002376biological_processimmune system process
B0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
B0003676molecular_functionnucleic acid binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006468biological_processprotein phosphorylation
B0006954biological_processinflammatory response
B0007249biological_processcanonical NF-kappaB signal transduction
B0009615biological_processresponse to virus
B0009967biological_processpositive regulation of signal transduction
B0010468biological_processregulation of gene expression
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0016239biological_processpositive regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019903molecular_functionprotein phosphatase binding
B0032479biological_processregulation of type I interferon production
B0032481biological_processpositive regulation of type I interferon production
B0032727biological_processpositive regulation of interferon-alpha production
B0032728biological_processpositive regulation of interferon-beta production
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034142biological_processtoll-like receptor 4 signaling pathway
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043231cellular_componentintracellular membrane-bounded organelle
B0044565biological_processdendritic cell proliferation
B0045087biological_processinnate immune response
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050830biological_processdefense response to Gram-positive bacterium
B0051219molecular_functionphosphoprotein binding
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0106310molecular_functionprotein serine kinase activity
B0140374biological_processantiviral innate immune response
B0140896biological_processcGAS/STING signaling pathway
B1902554cellular_componentserine/threonine protein kinase complex
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
B1904417biological_processpositive regulation of xenophagy
D0002218biological_processactivation of innate immune response
D0032481biological_processpositive regulation of type I interferon production
E0002218biological_processactivation of innate immune response
E0032481biological_processpositive regulation of type I interferon production
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue BX7 A 701
ChainResidue
ALEU15
ASER93
ATHR96
AGLY139
AMET142
ATHR156
AGLN17
AALA36
ALYS38
AMET86
AGLU87
APHE88
ACYS89
AGLY92

site_idAC2
Number of Residues17
Detailsbinding site for residue BX7 B 701
ChainResidue
BLEU15
BGLY16
BGLN17
BGLY18
BVAL23
BALA36
BLYS38
BMET86
BPHE88
BCYS89
BGLY92
BSER93
BTYR95
BGLY139
BMET142
BTHR156
BASP157

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........FAIK
ChainResidueDetails
ALEU15-LYS38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000305|PubMed:23453971, ECO:0000305|PubMed:23453972, ECO:0000305|PubMed:30842653
ChainResidueDetails
AASN135
BASN135

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU15
BLEU15

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ALYS38
BLYS38

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis and IKKB => ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23746807
ChainResidueDetails
AGLU172
BGLU172

site_idSWS_FT_FI5
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971
ChainResidueDetails
ALYS30
DTHR354
ALYS401
BLYS30
ETHR354
BLYS401

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545
ChainResidueDetails
DSER241
ESER241

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545
ChainResidueDetails
DSER355
ESER355

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25636800
ChainResidueDetails
DSER358
ESER358

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499
ChainResidueDetails
DSER366
ESER366

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013
ChainResidueDetails
DLYS236
ELYS236

site_idSWS_FT_FI11
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3
ChainResidueDetails
DLYS338
ELYS338

218853

PDB entries from 2024-04-24

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