5XQ0

Structural basis of kindlin-mediated integrin recognition and activation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fermitin family homolog 2,Integrin beta-1	polymer	485	56066.7	2	UniProt (Q8CIB5) UniProt (P09055) Pfam (PF18124) Pfam (PF00373) In PDB	Mus musculus (Mouse)	Kindlin-2,Pleckstrin homology domain-containing family C member 1,Fibronectin receptor subunit beta,VLA-4 subunit beta
2	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3		water	water		18.0	29	Chemie (HOH)

Sequence modifications

A, B: 1 - 680 (UniProt: Q8CIB5)

PDB	External Database	Details
His -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
-	Gly 168	deletion
-	Pro 169	deletion
-	Leu 170	deletion
-	Ile 171	deletion
-	Met 172	deletion
-	Pro 173	deletion
-	Gly 174	deletion
-	Ser 175	deletion
-	Gly 176	deletion
-	Ser 177	deletion
-	Ile 178	deletion
-	Tyr 179	deletion
-	Ser 180	deletion
-	Ser 181	deletion
-	Pro 182	deletion
-	Gly 183	deletion
-	Leu 184	deletion
-	Tyr 185	deletion
-	Ser 186	deletion
-	Lys 187	deletion
-	Thr 188	deletion
-	Met 189	deletion
-	Thr 190	deletion
-	Pro 191	deletion
-	Thr 192	deletion
-	Tyr 193	deletion
-	Asp 194	deletion
-	Ala 195	deletion
-	His 196	deletion
-	Asp 197	deletion
-	Gly 198	deletion
-	Ser 199	deletion
-	Pro 200	deletion
-	Leu 201	deletion
-	Ser 202	deletion
-	Pro 203	deletion
-	Thr 204	deletion
-	Ser 205	deletion
-	Ala 206	deletion
-	Trp 207	deletion
-	Phe 208	deletion
-	Gly 209	deletion
-	Asp 210	deletion
-	Ser 211	deletion
-	Ala 212	deletion
-	Leu 213	deletion
-	Ser 214	deletion
-	Glu 215	deletion
-	Gly 216	deletion
-	Asn 217	deletion
-	Asn 337	deletion
-	Asn 338	deletion
-	Ser 339	deletion
-	Asp 340	deletion
-	Lys 341	deletion
-	Glu 342	deletion
-	Val 343	deletion
-	Asp 344	deletion
-	Glu 345	deletion
-	Val 346	deletion
-	Asp 347	deletion
-	Ala 348	deletion
-	Ala 349	deletion
-	Leu 350	deletion
-	Ser 351	deletion
-	Asp 352	deletion
-	Leu 353	deletion
-	Glu 354	deletion
-	Ile 355	deletion
-	Thr 356	deletion
-	Leu 357	deletion
-	Glu 358	deletion
-	Gly 359	deletion
-	Gly 360	deletion
-	Lys 361	deletion
-	Thr 362	deletion
-	Ser 363	deletion
-	Thr 364	deletion
-	Ile 365	deletion
-	Leu 366	deletion
-	Gly 367	deletion
-	Asp 368	deletion
-	Ile 369	deletion
-	Thr 370	deletion
-	Ser 371	deletion
-	Ile 372	deletion
-	Pro 373	deletion
-	Glu 374	deletion
-	Leu 375	deletion
-	Ala 376	deletion
-	Asp 377	deletion
-	Tyr 378	deletion
-	Ile 379	deletion
-	Lys 380	deletion
-	Val 381	deletion
-	Phe 382	deletion
-	Lys 383	deletion
-	Pro 384	deletion
-	Lys 385	deletion
-	Lys 386	deletion
-	Leu 387	deletion
-	Thr 388	deletion
-	Leu 389	deletion
-	Lys 390	deletion
-	Gly 391	deletion
-	Tyr 392	deletion
-	Lys 393	deletion
-	Gln 394	deletion
-	Tyr 395	deletion
-	Trp 396	deletion
-	Cys 397	deletion
-	Thr 398	deletion
-	Phe 399	deletion
-	Lys 400	deletion
-	Asp 401	deletion
-	Thr 402	deletion
-	Ser 403	deletion
-	Ile 404	deletion
-	Ser 405	deletion
-	Cys 406	deletion
-	Tyr 407	deletion
-	Lys 408	deletion
-	Ser 409	deletion
-	Arg 410	deletion
-	Glu 411	deletion
-	Glu 412	deletion
-	Ser 413	deletion
-	Ser 414	deletion
-	Gly 415	deletion
-	Thr 416	deletion
-	Pro 417	deletion
-	Ala 418	deletion
-	His 419	deletion
-	Gln 420	deletion
-	Leu 421	deletion
-	Asn 422	deletion
-	Leu 423	deletion
-	Arg 424	deletion
-	Gly 425	deletion
-	Cys 426	deletion
-	Glu 427	deletion
-	Val 428	deletion
-	Thr 429	deletion
-	Pro 430	deletion
-	Asp 431	deletion
-	Val 432	deletion
-	Asn 433	deletion
-	Ile 434	deletion
-	Ser 435	deletion
-	Gly 436	deletion
-	Gln 437	deletion
-	Lys 438	deletion
-	Phe 439	deletion
-	Asn 440	deletion
-	Ile 441	deletion
-	Lys 442	deletion
-	Leu 443	deletion
-	Leu 444	deletion
-	Ile 445	deletion
-	Pro 446	deletion
-	Val 447	deletion
-	Ala 448	deletion
-	Glu 449	deletion
-	Gly 450	deletion
-	Met 451	deletion
-	Asn 452	deletion
-	Glu 453	deletion
-	Ile 454	deletion
-	Trp 455	deletion
-	Leu 456	deletion
-	Arg 457	deletion
-	Cys 458	deletion
-	Asp 459	deletion
-	Asn 460	deletion
-	Glu 461	deletion
-	Lys 462	deletion
-	Gln 463	deletion
-	Tyr 464	deletion
-	Ala 465	deletion
-	His 466	deletion
-	Trp 467	deletion
-	Met 468	deletion
-	Ala 469	deletion
-	Ala 470	deletion
-	Cys 471	deletion
-	Arg 472	deletion
-	Leu 473	deletion
-	Ala 474	deletion
-	Ser 475	deletion
-	Lys 476	deletion
-	Gly 477	deletion
-	Lys 478	deletion
-	Thr 479	deletion
-	Met 480	deletion
-	Ala 481	deletion
-	Asp 482	deletion
-	Ser 483	deletion
-	Ser 484	deletion
-	Tyr 485	deletion
-	Asn 486	deletion
-	Leu 487	deletion
-	Glu 488	deletion
-	Val 489	deletion
-	Gln 490	deletion
-	Asn 491	deletion
-	Ile 492	deletion
-	Leu 493	deletion
-	Ser 494	deletion
-	Phe 495	deletion
-	Leu 496	deletion
-	Lys 497	deletion
-	Met 498	deletion
-	Gln 499	deletion
-	His 500	deletion
-	Leu 501	deletion
-	Asn 502	deletion
-	Pro 503	deletion
-	Asp 504	deletion
-	Pro 505	deletion
-	Gln 506	deletion
-	Leu 507	deletion
-	Ile 508	deletion
-	Pro 509	deletion
-	Asp 510	deletion
-	Gln 511	deletion
-	Ile 512	deletion
Leu 681	-	linker
Val 682	-	linker
Pro 774	-	linker
Arg 775	-	linker
Gly 776	-	linker
Ser 777	-	linker
Gly 778	-	linker
Ser 779	-	linker
Gly 780	-	linker
Ser 781	-	linker
Gly 782	-	linker
Ser 783	-	linker

A, B: 784 - 798 (UniProt: P09055)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112133.4
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	112225.4

*Water molecules are not included.