5V5S

multi-drug efflux; membrane transport; RND superfamily; Drug resistance

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Outer membrane protein TolC	polymer	442	48673.8	3	UniProt (P02930) Pfam (PF02321) In PDB	Escherichia coli	Multidrug efflux pump subunit TolC,Outer membrane factor TolC
2	D, E, F, G, H...	Multidrug efflux pump subunit AcrA	polymer	397	42253.6	6	UniProt (P0AE07) Pfam (PF00529) Pfam (PF16576) UniProt (by SIFTS) (P0AE06) In PDB	Escherichia coli	AcrAB-TolC multidrug efflux pump subunit AcrA,Acriflavine resistance protein A
3	J, K, L	Multidrug efflux pump subunit AcrB	polymer	1049	113681.2	3	UniProt (P31224) Pfam (PF00873) In PDB	Escherichia coli	AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B

Sequence modifications

D, E, F, G, H, I: 1 - 397 (UniProt: P0AE07)

PDB	External Database	Details
Cys 273	Ser 273	conflict

J, K, L: 1 - 1049 (UniProt: P31224)

PDB	External Database	Details
Cys 258	Ser 258	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	740586.4
All*	Total formula weight	740586.4

*Water molecules are not included.