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5V5S

multi-drug efflux; membrane transport; RND superfamily; Drug resistance

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0009279cellular_componentcell outer membrane
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0014070biological_processresponse to organic cyclic compound
A0015125molecular_functionbile acid transmembrane transporter activity
A0015288molecular_functionporin activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015721biological_processbile acid and bile salt transport
A0016020cellular_componentmembrane
A0019867cellular_componentouter membrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042930biological_processenterobactin transport
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
A0098567cellular_componentperiplasmic side of plasma membrane
A0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
A1990196cellular_componentMacAB-TolC complex
A1990281cellular_componentefflux pump complex
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0009279cellular_componentcell outer membrane
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0014070biological_processresponse to organic cyclic compound
B0015125molecular_functionbile acid transmembrane transporter activity
B0015288molecular_functionporin activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015721biological_processbile acid and bile salt transport
B0016020cellular_componentmembrane
B0019867cellular_componentouter membrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042930biological_processenterobactin transport
B0046677biological_processresponse to antibiotic
B0055085biological_processtransmembrane transport
B0098567cellular_componentperiplasmic side of plasma membrane
B0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
B1990196cellular_componentMacAB-TolC complex
B1990281cellular_componentefflux pump complex
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0009279cellular_componentcell outer membrane
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0014070biological_processresponse to organic cyclic compound
C0015125molecular_functionbile acid transmembrane transporter activity
C0015288molecular_functionporin activity
C0015562molecular_functionefflux transmembrane transporter activity
C0015721biological_processbile acid and bile salt transport
C0016020cellular_componentmembrane
C0019867cellular_componentouter membrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0042930biological_processenterobactin transport
C0046677biological_processresponse to antibiotic
C0055085biological_processtransmembrane transport
C0098567cellular_componentperiplasmic side of plasma membrane
C0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
C1990196cellular_componentMacAB-TolC complex
C1990281cellular_componentefflux pump complex
C1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
D0016020cellular_componentmembrane
D0022857molecular_functiontransmembrane transporter activity
D0055085biological_processtransmembrane transport
E0016020cellular_componentmembrane
E0022857molecular_functiontransmembrane transporter activity
E0055085biological_processtransmembrane transport
F0016020cellular_componentmembrane
F0022857molecular_functiontransmembrane transporter activity
F0055085biological_processtransmembrane transport
G0016020cellular_componentmembrane
G0022857molecular_functiontransmembrane transporter activity
G0055085biological_processtransmembrane transport
H0016020cellular_componentmembrane
H0022857molecular_functiontransmembrane transporter activity
H0055085biological_processtransmembrane transport
I0016020cellular_componentmembrane
I0022857molecular_functiontransmembrane transporter activity
I0055085biological_processtransmembrane transport
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0015562molecular_functionefflux transmembrane transporter activity
J0016020cellular_componentmembrane
J0022857molecular_functiontransmembrane transporter activity
J0042802molecular_functionidentical protein binding
J0042908biological_processxenobiotic transport
J0042910molecular_functionxenobiotic transmembrane transporter activity
J0055085biological_processtransmembrane transport
J0098567cellular_componentperiplasmic side of plasma membrane
J0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
J1990281cellular_componentefflux pump complex
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0015562molecular_functionefflux transmembrane transporter activity
K0016020cellular_componentmembrane
K0022857molecular_functiontransmembrane transporter activity
K0042802molecular_functionidentical protein binding
K0042908biological_processxenobiotic transport
K0042910molecular_functionxenobiotic transmembrane transporter activity
K0055085biological_processtransmembrane transport
K0098567cellular_componentperiplasmic side of plasma membrane
K0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
K1990281cellular_componentefflux pump complex
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0015562molecular_functionefflux transmembrane transporter activity
L0016020cellular_componentmembrane
L0022857molecular_functiontransmembrane transporter activity
L0042802molecular_functionidentical protein binding
L0042908biological_processxenobiotic transport
L0042910molecular_functionxenobiotic transmembrane transporter activity
L0055085biological_processtransmembrane transport
L0098567cellular_componentperiplasmic side of plasma membrane
L0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
L1990281cellular_componentefflux pump complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues462
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996
ChainResidueDetails
JMET1-PRO9
KGLU414-ILE438
KALA491-THR538
KALA889-PRO898
KLEU944-LEU972
KILE1019-HIS1049
LMET1-PRO9
LLEU357-THR365
LGLU414-ILE438
LALA491-THR538
LALA889-PRO898
JLEU357-THR365
LLEU944-LEU972
LILE1019-HIS1049
JGLU414-ILE438
JALA491-THR538
JALA889-PRO898
JLEU944-LEU972
JILE1019-HIS1049
KMET1-PRO9
KLEU357-THR365

site_idSWS_FT_FI2
Number of Residues54
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
JILE10-LEU28
KILE10-LEU28
LILE10-LEU28

site_idSWS_FT_FI3
Number of Residues1932
DetailsTOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996
ChainResidueDetails
JLYS29-SER336
KPHE556-ASN871
KARG919-ASP924
KTHR993-GLY998
LLYS29-SER336
LPHE386-ASN391
LPHE458-ALA465
LPHE556-ASN871
LARG919-ASP924
LTHR993-GLY998
JPHE386-ASN391
JPHE458-ALA465
JPHE556-ASN871
JARG919-ASP924
JTHR993-GLY998
KLYS29-SER336
KPHE386-ASN391
KPHE458-ALA465

site_idSWS_FT_FI4
Number of Residues57
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
JILE337-TYR356
KILE337-TYR356
LILE337-TYR356

site_idSWS_FT_FI5
Number of Residues57
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
JLEU366-ALA385
KLEU366-ALA385
LLEU366-ALA385

site_idSWS_FT_FI6
Number of Residues63
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
JTHR392-VAL413
KTHR392-VAL413
LTHR392-VAL413

site_idSWS_FT_FI7
Number of Residues54
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
JGLN439-ALA457
KGLN439-ALA457
LGLN439-ALA457

site_idSWS_FT_FI8
Number of Residues72
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
JILE466-PRO490
KILE466-PRO490
LILE466-PRO490

site_idSWS_FT_FI9
Number of Residues48
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
JGLY539-LEU555
KGLY539-LEU555
LGLY539-LEU555

site_idSWS_FT_FI10
Number of Residues48
DetailsTRANSMEM: Helical; Name=8
ChainResidueDetails
JGLN872-LEU888
KGLN872-LEU888
LGLN872-LEU888

site_idSWS_FT_FI11
Number of Residues57
DetailsTRANSMEM: Helical; Name=9
ChainResidueDetails
JPHE899-PHE918
KPHE899-PHE918
LPHE899-PHE918

site_idSWS_FT_FI12
Number of Residues54
DetailsTRANSMEM: Helical; Name=10
ChainResidueDetails
JVAL925-ILE943
KVAL925-ILE943
LVAL925-ILE943

site_idSWS_FT_FI13
Number of Residues57
DetailsTRANSMEM: Helical; Name=11
ChainResidueDetails
JARG973-SER992
KARG973-SER992
LARG973-SER992

site_idSWS_FT_FI14
Number of Residues57
DetailsTRANSMEM: Helical; Name=12
ChainResidueDetails
JALA999-ALA1018
KALA999-ALA1018
LALA999-ALA1018

220113

PDB entries from 2024-05-22

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