5MWJ
Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transducin-like enhancer protein 1 | polymer | 337 | 36853.5 | 2 | UniProt (Q04724) Pfam (PF00400) In PDB | Homo sapiens (Human) | E(Sp1) homolog,Enhancer of split groucho-like protein 1,ESG1 |
2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
3 | A, B | pepide inhibtor | non-polymer | 845.0 | 2 | Chemie (EBU) | |||
4 | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 443 - 770 (UniProt: Q04724)
PDB | External Database | Details |
---|---|---|
Asp 434 | - | expression tag |
Tyr 435 | - | expression tag |
Phe 436 | - | expression tag |
Gln 437 | - | expression tag |
Gly 438 | - | expression tag |
Ala 439 | - | expression tag |
Met 440 | - | expression tag |
Gly 441 | - | expression tag |
Ser 442 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73706.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1768.1 | |
All* | Total formula weight | 75475.1 |