5M6U
HUMAN PI3KDELTA IN COMPLEX WITH LASW1579
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 1011 | 115728.6 | 1 | UniProt (O00329) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta |
2 | B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 724 | 83668.2 | 1 | UniProt (P27986) Pfam (PF00620) Pfam (PF00017) Pfam (PF16454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
3 | A | 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile | non-polymer | 372.4 | 1 | Chemie (7KA) |
Sequence modifications
B: 1 - 724 (UniProt: P27986)
PDB | External Database | Details |
---|---|---|
Asp 469 | Glu 469 | conflict |
Thr 519 | Lys 519 | conflict |
Glu 529 | Asp 529 | conflict |
Val 539 | Ile 539 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 199396.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 372.4 | |
All* | Total formula weight | 199769.1 |