Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5M6U

HUMAN PI3KDELTA IN COMPLEX WITH LASW1579

Summary for 5M6U
Entry DOI10.2210/pdb5m6u/pdb
DescriptorPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile (3 entities in total)
Functional Keywordspi3kdelta kinase, proteros biostructures gmbh, transferase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight199769.15
Authors
Segarra, V.,Hernandez, B.,Lozoya, E.,Blaesse, M.,Hoeppner, S.,Jestel, A. (deposition date: 2016-10-26, release date: 2017-02-01, Last modification date: 2024-01-17)
Primary citationErra, M.,Taltavull, J.,Greco, A.,Bernal, F.J.,Caturla, J.F.,Gracia, J.,Dominguez, M.,Sabate, M.,Paris, S.,Soria, S.,Hernandez, B.,Armengol, C.,Cabedo, J.,Bravo, M.,Calama, E.,Miralpeix, M.,Lehner, M.D.
Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8:118-123, 2017
Cited by
PubMed: 28105286
DOI: 10.1021/acsmedchemlett.6b00438
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.85 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon