5K33

Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ig gamma-1 chain C region	polymer	227	25567.9	1	UniProt (P01857) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	C	Receptor tyrosine-protein kinase erbB-2	polymer	607	66989.1	1	UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB	Homo sapiens (Human)	Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2
3	B	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	D	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 225 - 446 (UniProt: P01857)

PDB	External Database	Details
Tyr 358	Leu 241	engineered mutation
Leu 359	Thr 242	engineered mutation
Ser 360	Lys 243	engineered mutation
Asp 361	Asn 244	engineered mutation
Ser 362	Gln 245	engineered mutation
Pro 413	-	insertion
Arg 414	-	insertion
His 415	-	insertion
Ser 415	-	insertion
Glu 415	-	insertion
Thr 415	Asp 296	engineered mutation
Met 415	Lys 297	engineered mutation
Arg 415	Ser 298	engineered mutation
Ala 418	Gln 301	engineered mutation
His 419	Gln 302	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	92557.0
Branched	Number of molecules	2
	Total formula weight	1659.5
Non-Polymers*	Number of molecules	3
	Total formula weight	534.5
All*	Total formula weight	94751.0

*Water molecules are not included.