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5K33

Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19

Summary for 5K33
Entry DOI10.2210/pdb5k33/pdb
DescriptorIg gamma-1 chain C region, Receptor tyrosine-protein kinase erbB-2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywordsimmune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, human epidermal growth factor receptor 2, her2/neu, erbb-2, cell surface receptor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight94751.04
Authors
Humm, A.,Lobner, E.,Goritzer, K.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2016-05-19, release date: 2017-04-12, Last modification date: 2024-01-10)
Primary citationLobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.
Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25:878-889.e5, 2017
Cited by
PubMed: 28528777
DOI: 10.1016/j.str.2017.04.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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