4XT2
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, D | Aryl hydrocarbon receptor nuclear translocator | polymer | 121 | 14243.1 | 2 | UniProt (P27540) Pfam (PF14598) In PDB | Homo sapiens (Human) | ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2,Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta |
2 | A, C | Endothelial PAS domain-containing protein 1 | polymer | 117 | 13538.3 | 2 | UniProt (Q99814) Pfam (PF14598) In PDB | Homo sapiens (Human) | EPAS-1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, bHLHe73, HIF-1-alpha-like factor, HLF, Hypoxia-inducible factor 2-alpha, HIF2-alpha, Member of PAS protein 2, PAS domain-containing protein 2 |
3 | A, C | (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine | non-polymer | 435.1 | 2 | Chemie (43L) | |||
4 | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
B, D: 356 - 470 (UniProt: P27540)
A, C: 239 - 350 (UniProt: Q99814)
PDB | External Database | Details |
---|---|---|
Gly 350 | - | expression tag |
Glu 351 | - | expression tag |
Phe 352 | - | expression tag |
Lys 353 | - | expression tag |
Gly 354 | - | expression tag |
Leu 355 | - | expression tag |
Arg 362 | Glu 348 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 234 | - | expression tag |
Glu 235 | - | expression tag |
Phe 236 | - | expression tag |
Lys 237 | - | expression tag |
Gly 238 | - | expression tag |
Glu 247 | Arg 247 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55562.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 870.2 | |
All* | Total formula weight | 56433.0 |