4XT2
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 43L A 401 |
| Chain | Residue |
| A | HIS248 |
| A | GLY323 |
| A | ASN341 |
| A | HOH505 |
| A | MET252 |
| A | PHE280 |
| A | TYR281 |
| A | MET289 |
| A | SER292 |
| A | HIS293 |
| A | VAL302 |
| A | TYR307 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 43L C 401 |
| Chain | Residue |
| C | HIS248 |
| C | MET252 |
| C | TYR281 |
| C | MET289 |
| C | SER292 |
| C | HIS293 |
| C | VAL302 |
| C | TYR307 |
| C | GLY323 |
| C | CYS339 |
| C | ASN341 |
| C | HOH515 |
| C | HOH519 |
