4XT2
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
Summary for 4XT2
Entry DOI | 10.2210/pdb4xt2/pdb |
Related | 3F1O 3F1P 3H82 3HW7 4GHI 4GS9 4LPZ |
Descriptor | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, ... (4 entities in total) |
Functional Keywords | transcription factor, hypoxia inducible factor, inhibitor, cancer, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 56433.03 |
Authors | Scheuermann, T.H.,Gardner, K.H. (deposition date: 2015-01-22, release date: 2015-12-09, Last modification date: 2023-09-27) |
Primary citation | Scheuermann, T.H.,Stroud, D.,Sleet, C.E.,Bayeh, L.,Shokri, C.,Wang, H.,Caldwell, C.G.,Longgood, J.,MacMillan, J.B.,Bruick, R.K.,Gardner, K.H.,Tambar, U.K. Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. J.Med.Chem., 58:5930-5941, 2015 Cited by PubMed: 26226049DOI: 10.1021/acs.jmedchem.5b00529 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.698 Å) |
Structure validation
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