4JIJ
Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | P, Q | fluorogenic peptidic substrate (8MC)PLG(PHI)(DNW)AR(NH2) | polymer | 9 | 1253.1 | 2 | |||
2 | A, B | Matrix metalloproteinase-9 | polymer | 164 | 18280.3 | 2 | UniProt (P14780) Pfam (PF00413) In PDB | Homo sapiens (human) | MMP-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB, 67 kDa matrix metalloproteinase-9, 82 kDa matrix metalloproteinase-9 |
3 | A, Q | AZIDE ION | non-polymer | 42.0 | 2 | Chemie (AZI) | |||
4 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
5 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
6 | A, B | STRONTIUM ION | non-polymer | 87.6 | 4 | Chemie (SR) | |||
7 | A, B | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 2 | Chemie (PGO) | |||
8 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
9 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
10 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
11 | water | water | 18.0 | 410 | Chemie (HOH) |
Sequence modifications
A, B: 107 - 216 (UniProt: P14780)
A, B: 217 - 269 (UniProt: P14780)
A, B: 217 - 269 (UniProt: P14780)
PDB | External Database | Details |
---|---|---|
Ala 227 | Glu 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 39066.7 | |
Non-Polymers* | Number of molecules | 21 |
Total formula weight | 1467.1 | |
All* | Total formula weight | 40533.8 |