4IGD

Crystal structure of the zymogen catalytic region of Human MASP-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mannan-binding lectin serine protease 1	polymer	406	45489.9	1	UniProt (P48740) Pfam (PF00084) Pfam (PF00089) In PDB	Homo sapiens (human)	Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5
2	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3		water	water		18.0	91	Chemie (HOH)

Sequence modifications

A: 298 - 699 (UniProt: P48740)

PDB	External Database	Details
Ala 294	-	expression tag
Ser 295	-	expression tag
Met 296	-	expression tag
Thr 297	-	expression tag
Gln 448	Arg 448	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45489.9
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	45674.1

*Water molecules are not included.