4IGD

Crystal structure of the zymogen catalytic region of Human MASP-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 701

Chain	Residue
A	HIS468
A	PHE474
A	HOH873
A	HOH874

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 702

Chain	Residue
A	LYS623
A	TRP668
A	LYS674
A	HOH857

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
A	VAL486-CYS491

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcaGDSGGPMV

Chain	Residue	Details
A	ASP640-VAL651

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
A	HIS490
A	ASP552
A	SER646

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:11290788

Chain	Residue	Details
A	GLN448

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490

Chain	Residue	Details
A	ASN385

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11290788, ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN407

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