4IGD

Crystal structure of the zymogen catalytic region of Human MASP-1

Summary for 4IGD

Entry DOI	10.2210/pdb4igd/pdb
Descriptor	Mannan-binding lectin serine protease 1, GLYCEROL (3 entities in total)
Functional Keywords	complement, immune response, innate immunity, beta barrel, hydrolase, serine protease, glycosylation
Biological source	Homo sapiens (human)
Cellular location	Secreted: P48740
Total number of polymer chains	1
Total formula weight	45674.11
Authors	Harmat, V.,Megyeri, M.,Vegh, A.,Dobo, J. (deposition date: 2012-12-17, release date: 2013-02-13, Last modification date: 2023-11-08)
Primary citation	Megyeri, M.,Harmat, V.,Major, B.,Vegh, A.,Balczer, J.,Heja, D.,Szilagyi, K.,Datz, D.,Pal, G.,Zavodszky, P.,Gal, P.,Dobo, J. Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway J.Biol.Chem., 288:8922-8934, 2013 Cited by PubMed: 23386610 DOI: 10.1074/jbc.M112.446500 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation