3RNU

Structural Basis of Cytosolic DNA Sensing by Innate Immune Receptors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Gamma-interferon-inducible protein 16	polymer	204	22896.3	4	UniProt (Q16666) Pfam (PF02760) In PDB	Homo sapiens (human)	Ifi-16, Interferon-inducible myeloid differentiation transcriptional activator
2	K	DNA (5'-D(*GP*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*G)-3')	polymer	16	4965.3	1
3	L	DNA (5'-D(*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*GP*GP*CP*C)-3')	polymer	16	4831.1	1
4	A, B, C, D	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT)
5	B, D	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6		water	water		18.0	105	Chemie (HOH)

Sequence modifications

A, B, C, D: 571 - 766 (UniProt: Q16666)

PDB	External Database	Details
Gly 567	-	expression tag
Ser 568	-	expression tag
Val 569	-	expression tag
Asp 570	-	expression tag
Ala 767	-	expression tag
Ala 768	-	expression tag
Ala 769	-	expression tag
Ser 770	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	101381.5
Non-Polymers*	Number of molecules	7
	Total formula weight	354.3
All*	Total formula weight	101735.7

*Water molecules are not included.