3LFV
crystal structure of unliganded PDE5A GAF domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 431 | 48862.5 | 2 | UniProt (O76074) Pfam (PF01590) In PDB | Homo sapiens (human) | cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE |
Sequence modifications
A, B: 98 - 518 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Ala 90 | - | expression tag |
| Met 91 | - | expression tag |
| Glu 92 | - | expression tag |
| His 93 | - | expression tag |
| Met 94 | - | expression tag |
| Ala 95 | - | expression tag |
| Ser 96 | - | expression tag |
| Met 97 | - | expression tag |
| Ser 149 | Cys 149 | engineered mutation |
| Arg 519 | - | expression tag |
| Asn 520 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97724.9 | |
| All* | Total formula weight | 97724.9 |
