2WD0

CRYSTAL STRUCTURE OF NONSYNDROMIC DEAFNESS (DFNB12) ASSOCIATED MUTANT D124G OF MOUSE CADHERIN-23 EC1-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	CADHERIN-23	polymer	214	23798.4	2	UniProt (Q99PF4) Pfam (PF00028) In PDB	MUS MUSCULUS (HOUSE MOUSE)	OTOCADHERIN
2	A, C	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
3	A, C	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4	A, C	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
5		water	water		18.0	52	Chemie (HOH)

Sequence modifications

A, C: 2 - 206 (UniProt: Q99PF4)

PDB	External Database	Details
Met 1	-	expression tag
Gly 102	Asp 124	engineered mutation
Leu 207	-	expression tag
Glu 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47596.8
Non-Polymers*	Number of molecules	11
	Total formula weight	392.8
All*	Total formula weight	47989.6

*Water molecules are not included.