2W4O

Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV	polymer	349	39326.3	1	UniProt (Q16566) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	CAM KINASE-GR, CAMK4A
2	A	5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE	non-polymer		425.4	1	Chemie (DKI)
3		water	water		18.0	115	Chemie (HOH)

Sequence modifications

A: 15 - 340 (UniProt: Q16566)

PDB	External Database	Details
Met -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag
Val 2	-	expression tag
Asp 3	-	expression tag
Leu 4	-	expression tag
Gly 5	-	expression tag
Thr 6	-	expression tag
Glu 7	-	expression tag
Asn 8	-	expression tag
Leu 9	-	expression tag
Tyr 10	-	expression tag
Phe 11	-	expression tag
Gln 12	-	expression tag
Ser 13	-	expression tag
Met 14	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	39326.3
Non-Polymers*	Number of molecules	1
	Total formula weight	425.4
All*	Total formula weight	39751.7

*Water molecules are not included.