2W4O

Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DKI A 1338

Chain	Residue
A	LEU52
A	ASP185
A	ARG245
A	GLY53
A	VAL60
A	GLU119
A	LEU120
A	VAL121
A	GLU168
A	LEU171
A	ALA184

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGATSIVYrCkqkgtqkp..........YALK

Chain	Residue	Details
A	LEU52-LYS75

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLY

Chain	Residue	Details
A	ILE160-TYR172

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP164

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU52
A	LYS75

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMKK1 and CaMKK2 => ECO:0000269|PubMed:15143065, ECO:0000269|PubMed:19506079, ECO:0000269|PubMed:8702940

Chain	Residue	Details
A	THR200

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P13234

Chain	Residue	Details
A	SER336

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:19506079

Chain	Residue	Details
A	THR57

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site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:19506079

Chain	Residue	Details
A	SER58
A	SER137
A	SER189

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