2BCJ

Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	G-protein-coupled receptor kinase 2	polymer	689	79749.9	1	UniProt (P21146) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB	Bos taurus (Bovine)	Beta-ARK-1, Beta-adrenergic receptor kinase 1
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37311.8	1	UniProt (P62871) Pfam (PF00400) In PDB	Bos taurus (Bovine)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7845.1	1	UniProt (P63212) Pfam (PF00631) In PDB	Bos taurus (Bovine)	G gamma-I
4	Q	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(q) subunit alpha chimera	polymer	353	41298.9	1	UniProt (P10824) UniProt (P21279) Pfam (PF00503) In PDB	Rattus norvegicus (Rat)	Adenylate cyclase-inhibiting G alpha protein,Guanine nucleotide-binding protein alpha-q
5	Q	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	Q	TETRAFLUOROALUMINATE ION	non-polymer		103.0	1	Chemie (ALF)
7	Q	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
8		water	water		18.0	5	Chemie (HOH)

Sequence modifications

A: 1 - 689 (UniProt: P21146)

PDB	External Database	Details
Ala 670	Ser 670	engineered mutation

B: 2 - 340 (UniProt: P62871)

PDB	External Database	Details
Ace 1	-	acetylation

G: 1 - 71 (UniProt: P63212)

PDB	External Database	Details
Ser 68	Cys 68	engineered mutation

Q: 7 - 34 (UniProt: P10824)

PDB	External Database	Details
Arg 35	-	linker
Ser 36	-	linker

Q: 37 - 359 (UniProt: P21279)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.