1IKX
K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | POL POLYPROTEIN | polymer | 560 | 64501.0 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus 1 | reverse transcriptase |
| 2 | B | POL POLYPROTEIN | polymer | 427 | 49912.3 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus 1 | reverse transcriptase |
| 3 | A | 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE | non-polymer | 306.8 | 1 | Chemie (PNU) | |||
| 4 | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1001 - 1427 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 270 | engineered mutation |
| Gln 478 | Glu 645 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 1103 | Lys 270 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114413.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 306.8 | |
| All* | Total formula weight | 114720.1 |
