1IKX

K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PNU A 2000

Chain	Residue
A	PRO95
A	LEU234
A	HIS235
A	PRO236
A	TYR318
A	LEU100
A	LYS101
A	ASN103
A	VAL179
A	TYR181
A	TYR188
A	PHE227
A	TRP229

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	ZN_FING: CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
B	LYS1223-THR1240

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site_id	SWS_FT_FI2
Number of Residues	17
Details	ZN_FING: CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
B	ILE1244-VAL1261

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029

Chain	Residue	Details
B	ARG1358

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cis/trans isomerization of proline peptide bond; by human PPIA/CYPA => ECO:0000250

Chain	Residue	Details
B	ASN1054

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Cleavage; by viral protease => ECO:0000250

Chain	Residue	Details
B	GLY1196
B	LEU1210

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000255

Chain	Residue	Details
B	ASN1265
A	LEU210

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site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Cleavage; by viral protease

Chain	Residue	Details
B	GLY1273
B	GLY1333

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site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034

Chain	Residue	Details
B	LYS1220
B	GLN1242

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site_id	SWS_FT_FI9
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069

Chain	Residue	Details
A	GLU432

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site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034

Chain	Residue	Details
A	LYS220
A	GLN242

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