3L2C
 
 | | Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA | | Descriptor: | FOXO consensus binding sequence, minus strand, plus strand, ... | | Authors: | Boura, E, Silhan, J, Sulc, M, Brynda, J, Obsilova, V, Obsil, T. | | Deposit date: | 2009-12-15 | | Release date: | 2009-12-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.868 Å) | | Cite: | Structure of the human FOXO4-DBD-DNA complex at 1.9 A resolution reveals new details of FOXO binding to the DNA
Acta Crystallogr.,Sect.D, 66, 2010
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6QVW
 | | Solution structure of the free FOXO1 DNA binding domain | | Descriptor: | Forkhead box protein O1 | | Authors: | Psenakova, K, Obsil, T, Veverka, V, Obsilova, V, Kohoutova, K. | | Deposit date: | 2019-03-05 | | Release date: | 2019-09-04 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics.
Cells, 8, 2019
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7V9B
 | | Crystal Structure of 14-3-3 epsilon with FOXO3a peptide | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ... | | Authors: | Mathivanan, S, Kamariah, N. | | Deposit date: | 2021-08-24 | | Release date: | 2022-08-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins.
Acs Omega, 7, 2022
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2UZK
 | | Crystal structure of the human FOXO3a-DBD bound to DNA | | Descriptor: | 5'-D(*CP*TP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*AP*G)-3', FORKHEAD BOX PROTEIN O3A | | Authors: | Tsai, K.-L, Sun, Y.-J, Huang, C.-Y, Yang, J.-Y, Hung, M.-C, Hsiao, C.-D. | | Deposit date: | 2007-04-30 | | Release date: | 2008-05-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure of the Human Foxo3A-Dbd/DNA Complex Suggests the Effects of Post-Translational Modification.
Nucleic Acids Res., 35, 2007
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2MBF
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3CO7
 | | Crystal Structure of FoxO1 DBD Bound to DBE2 DNA | | Descriptor: | DNA (5'-D(*DCP*DAP*DAP*DAP*DAP*DTP*DGP*DTP*DAP*DAP*DAP*DCP*DAP*DAP*DGP*DA)-3'), DNA (5'-D(*DTP*DCP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DAP*DTP*DTP*DTP*DTP*DG)-3'), Forkhead box protein O1 | | Authors: | Brent, M.M, Anand, R, Marmorstein, R. | | Deposit date: | 2008-03-27 | | Release date: | 2008-09-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16, 2008
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3COA
 | | Crystal Structure of FoxO1 DBD Bound to IRE DNA | | Descriptor: | CALCIUM ION, DNA (5'-D(*DCP*DAP*DAP*DGP*DCP*DAP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DCP*DCP*DA)-3'), DNA (5'-D(*DTP*DGP*DGP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DG)-3'), ... | | Authors: | Brent, M.M, Anand, R, Marmorstein, R. | | Deposit date: | 2008-03-27 | | Release date: | 2008-09-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16, 2008
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3CO6
 | | Crystal Structure of FoxO1 DBD Bound to DBE1 DNA | | Descriptor: | CALCIUM ION, CHLORIDE ION, DNA (5'-D(*DCP*DAP*DAP*DGP*DGP*DTP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DCP*DCP*DA)-3'), ... | | Authors: | Brent, M.M, Anand, R, Marmorstein, R. | | Deposit date: | 2008-03-27 | | Release date: | 2008-09-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16, 2008
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2K86
 | | Solution Structure of FOXO3a Forkhead domain | | Descriptor: | Forkhead box protein O3 | | Authors: | Wang, F, Marshall, C.B, Li, G, Plevin, M.J, Ikura, M. | | Deposit date: | 2008-09-02 | | Release date: | 2008-10-14 | | Last modified: | 2020-02-19 | | Method: | SOLUTION NMR | | Cite: | Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
J.Mol.Biol., 384, 2008
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7UPZ
 | | Structural basis for cell type specific DNA binding of C/EBPbeta: the case of cell cycle inhibitor p15INK4b promoter | | Descriptor: | CCAAT/enhancer-binding protein beta, DNA (5'-D(*AP*TP*TP*CP*TP*TP*AP*AP*GP*AP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*CP*TP*TP*TP*CP*TP*TP*AP*AP*GP*AP*A)-3') | | Authors: | Lountos, G.T, Cherry, S, Tropea, J.E, Wlodawer, A, Miller, M. | | Deposit date: | 2022-04-18 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.487 Å) | | Cite: | Structural basis for cell type specific DNA binding of C/EBP beta : The case of cell cycle inhibitor p15INK4b promoter.
J.Struct.Biol., 214, 2022
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5WRM
 | | Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y658 peptide | | Descriptor: | AP-2 complex subunit mu, Insulin receptor substrate 1 | | Authors: | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | | Deposit date: | 2016-12-02 | | Release date: | 2017-12-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.597 Å) | | Cite: | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
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5WRL
 | | Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y628 peptide | | Descriptor: | AP-2 complex subunit mu, Insulin receptor substrate 1 | | Authors: | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | | Deposit date: | 2016-12-02 | | Release date: | 2017-12-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.095 Å) | | Cite: | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
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5WRK
 | | Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y608 peptide | | Descriptor: | AP-2 complex subunit mu, Insulin receptor substrate 1, NICKEL (II) ION | | Authors: | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | | Deposit date: | 2016-12-02 | | Release date: | 2017-12-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
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8ATZ
 | | Crystal structure of PPAR gamma (PPARG) in complex with SA112 (compound 2). | | Descriptor: | 2-[4-chloranyl-6-[[3-(2-phenylethoxy)phenyl]amino]pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma | | Authors: | Chaikuad, A, Arifi, S, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-08-24 | | Release date: | 2023-07-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation.
J.Am.Chem.Soc., 145, 2023
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8ATY
 | | Crystal structure of PPAR gamma (PPARG) in complex with JP85 (compound 1). | | Descriptor: | 2-[4-chloranyl-6-(5,6,7,8-tetrahydronaphthalen-1-ylamino)pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma | | Authors: | Chaikuad, A, Pollinger, J, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-08-24 | | Release date: | 2023-07-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation.
J.Am.Chem.Soc., 145, 2023
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8CPH
 | | Crystal structure of PPAR gamma (PPARG) in complex with WY-14643 (inactive form) | | Descriptor: | 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, Peroxisome proliferator-activated receptor gamma | | Authors: | Chaikuad, A, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-03-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-07-19 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation.
J.Am.Chem.Soc., 145, 2023
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8CPJ
 | | Crystal structure of PPAR gamma (PPARG) in an inactive form | | Descriptor: | 1,2-ETHANEDIOL, Peroxisome proliferator-activated receptor gamma | | Authors: | Chaikuad, A, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-03-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-07-19 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation.
J.Am.Chem.Soc., 145, 2023
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8CPI
 | | Crystal structure of PPAR gamma (PPARG) in complex with WY-14643 | | Descriptor: | 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, Peroxisome proliferator-activated receptor gamma | | Authors: | Chaikuad, A, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-03-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-07-19 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation.
J.Am.Chem.Soc., 145, 2023
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