8RXB
| Human UPF1 CH domain in complex with SMG6 peptide | Descriptor: | Regulator of nonsense transcripts 1, Telomerase-binding protein EST1A, ZINC ION | Authors: | Langer, L, Basquin, J, Conti, E. | Deposit date: | 2024-02-06 | Release date: | 2024-05-15 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2. Nucleic Acids Res., 52, 2024
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2XZP
| Upf1 helicase | Descriptor: | GLYCEROL, MALONATE ION, REGULATOR OF NONSENSE TRANSCRIPTS 1 | Authors: | Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E. | Deposit date: | 2010-11-26 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2. Mol.Cell, 41, 2011
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2XZO
| Upf1 helicase - RNA complex | Descriptor: | 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3', ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E. | Deposit date: | 2010-11-26 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.395 Å) | Cite: | Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2. Mol.Cell, 41, 2011
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2XZL
| Upf1-RNA complex | Descriptor: | 5- R(*UP*UP*UP*UP*UP*UP*UP*UP*U) -3, ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT HELICASE NAM7, ... | Authors: | Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E. | Deposit date: | 2010-11-26 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2. Mol.Cell, 41, 2011
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2IYK
| Crystal structure of the UPF2-interacting domain of nonsense mediated mRNA decay factor UPF1 | Descriptor: | REGULATOR OF NONSENSE TRANSCRIPTS 1, ZINC ION | Authors: | Kadlec, J, Guilligay, D, Ravelli, R.B, Cusack, S. | Deposit date: | 2006-07-18 | Release date: | 2006-08-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal Structure of the Upf2-Interacting Domain of Nonsense-Mediated Mrna Decay Factor Upf1. RNA, 12, 2006
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6EJ5
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2WJY
| Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 Orthorhombic form | Descriptor: | REGULATOR OF NONSENSE TRANSCRIPTS 1, SULFATE ION, ZINC ION | Authors: | Clerici, M, Mourao, A, Gutsche, I, Gehring, N.H, Hentze, M.W, Kulozik, A, Kadlec, J, Sattler, M, Cusack, S. | Deposit date: | 2009-06-01 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2. Embo J., 28, 2009
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2WJV
| Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 | Descriptor: | REGULATOR OF NONSENSE TRANSCRIPTS 1, REGULATOR OF NONSENSE TRANSCRIPTS 2, SULFATE ION, ... | Authors: | Clerici, M, Mourao, A, Gutsche, I, Gehring, N.H, Hentze, M.W, Kulozik, A, Kadlec, J, Sattler, M, Cusack, S. | Deposit date: | 2009-06-01 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2. Embo J., 28, 2009
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2GK6
| Structural and Functional insights into the human Upf1 helicase core | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Cheng, Z, Muhlrad, D, Parker, R, Song, H. | Deposit date: | 2006-03-31 | Release date: | 2007-01-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional insights into the human Upf1 helicase core Embo J., 26, 2007
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2GK7
| Structural and Functional insights into the human Upf1 helicase core | Descriptor: | PHOSPHATE ION, Regulator of nonsense transcripts 1 | Authors: | Cheng, Z, Muhlrad, D, Parker, R, Song, H. | Deposit date: | 2006-03-31 | Release date: | 2007-01-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and functional insights into the human Upf1 helicase core Embo J., 26, 2007
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2GJK
| Structural and functional insights into the human Upf1 helicase core | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Regulator of nonsense transcripts 1 | Authors: | Cheng, Z, Muhlrad, D, Parker, R, Song, H. | Deposit date: | 2006-03-31 | Release date: | 2007-01-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and functional insights into the human Upf1 helicase core Embo J., 26, 2007
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4UM2
| Crystal structure of the TPR domain of SMG6 | Descriptor: | GLYCEROL, TELOMERASE-BINDING PROTEIN EST1A | Authors: | Chakrabarti, S, Bonneau, F, Schuessler, S, Eppinger, E, Conti, E. | Deposit date: | 2014-05-14 | Release date: | 2014-07-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phospho-Dependent and Phospho-Independent Interactions of the Helicase Upf1 with the Nmd Factors Smg5-Smg7 and Smg6. Nucleic Acids Res., 42, 2014
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6Z3R
| Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Langer, L.M, Gat, Y, Conti, E. | Deposit date: | 2020-05-21 | Release date: | 2020-06-24 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife, 9, 2020
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5MZN
| Helicase Sen1 | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Leonaite, B, Basquin, J, Conti, E. | Deposit date: | 2017-02-01 | Release date: | 2017-04-19 | Last modified: | 2017-06-14 | Method: | X-RAY DIFFRACTION (1.787 Å) | Cite: | Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. EMBO J., 36, 2017
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5WWP
| Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13) | Descriptor: | ORF1ab, SULFATE ION, ZINC ION | Authors: | Hao, W, Wojdyla, J.A, Zhao, R, Han, R, Das, R, Zlatev, I, Manoharan, M, Wang, M, Cui, S. | Deposit date: | 2017-01-03 | Release date: | 2017-07-05 | Last modified: | 2021-09-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of Middle East respiratory syndrome coronavirus helicase PLoS Pathog., 13, 2017
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8RD3
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4M7B
| Human tankyrase 2 - catalytic Parp domain in complex with an inhibitor UPF1854 | Descriptor: | 4-{2-[(6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-yl)amino]ethyl}phenol, SULFATE ION, Tankyrase-2, ... | Authors: | Karlberg, T, Camaioni, E, Schuler, H. | Deposit date: | 2013-08-12 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors. J.Med.Chem., 57, 2014
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4LUN
| Structure of the N-terminal mIF4G domain from S. cerevisiae Upf2, a protein involved in the degradation of mRNAs containing premature stop codons | Descriptor: | CHLORIDE ION, Nonsense-mediated mRNA decay protein 2 | Authors: | Fourati, Z, Roy, B, Millan, C, Courreux, P.D, Kervestin, S, van Tilbeurgh, H, He, F, Uson, I, Jacobson, A, Graille, M. | Deposit date: | 2013-07-25 | Release date: | 2014-07-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.641 Å) | Cite: | A highly conserved region essential for NMD in the Upf2 N-terminal domain. J.Mol.Biol., 426, 2014
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1YA0
| Crystal structure of the N-terminal domain of human SMG7 | Descriptor: | SMG-7 transcript variant 2, SULFATE ION | Authors: | Fukuhara, N, Ebert, J, Unterholzner, L, Lindner, D, Izaurralde, E, Conti, E. | Deposit date: | 2004-12-17 | Release date: | 2005-03-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | SMG7 Is a 14-3-3-like Adaptor in the Nonsense-Mediated mRNA Decay Pathway. Mol.Cell, 17, 2005
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4CEM
| Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2 | Descriptor: | REGULATOR OF NONSENSE TRANSCRIPTS 2 | Authors: | Clerici, M, Deniaud, A, Boehm, V, Gehring, N.H, Schaffitzel, C, Cusack, S. | Deposit date: | 2013-11-11 | Release date: | 2013-12-11 | Last modified: | 2014-03-12 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and Functional Analysis of the Three Mif4G Domains of Nonsense-Mediated Decay Factor Upf2. Nucleic Acids Res., 42, 2014
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4CEK
| Crystal structure of the second MIF4G domain of human nonsense mediated decay factor UPF2 | Descriptor: | REGULATOR OF NONSENSE TRANSCRIPTS 2 | Authors: | Clerici, M, Deniaud, A, Boehm, V, Gehring, N.H, Schaffitzel, C, Cusack, S. | Deposit date: | 2013-11-11 | Release date: | 2013-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural and Functional Analysis of the Three Mif4G Domains of Nonsense-Mediated Decay Factor Upf2. Nucleic Acids Res., 42, 2014
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3ZHE
| Structure of the C. elegans SMG5-SMG7 complex | Descriptor: | NONSENSE-MEDIATED MRNA DECAY PROTEIN, PROTEIN SMG-7 | Authors: | Jonas, S, Weichenrieder, O, Izaurralde, E. | Deposit date: | 2012-12-21 | Release date: | 2013-02-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | An Unusual Arrangement of Two 14-3-3-Like Domains in the Smg5-Smg7 Heterodimer is Required for Efficient Nonsense-Mediated Mrna Decay. Genes Dev., 27, 2013
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4B3G
| crystal structure of Ighmbp2 helicase in complex with RNA | Descriptor: | DNA-BINDING PROTEIN SMUBP-2, RNA (5'-(AP*AP*AP*AP*AP*AP*AP*AP*AP)-3') | Authors: | Lim, S.C, Song, H. | Deposit date: | 2012-07-24 | Release date: | 2012-09-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Ighmbp2 Helicase Structure Reveals the Molecular Basis for Disease-Causing Mutations in Dmsa1. Nucleic Acids Res., 40, 2012
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4B3F
| crystal structure of Ighmbp2 helicase | Descriptor: | DNA-BINDING PROTEIN SMUBP-2, PHOSPHATE ION | Authors: | Lim, S.C, Song, H. | Deposit date: | 2012-07-24 | Release date: | 2012-09-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Ighmbp2 Helicase Structure Reveals the Molecular Basis for Disease-Causing Mutations in Dmsa1. Nucleic Acids Res., 40, 2012
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6JYT
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