4M7B

Human tankyrase 2 - catalytic Parp domain in complex with an inhibitor UPF1854

Summary for 4M7B

• Entry DOI: 10.2210/pdb4m7b/pdb
• Related: 3P0Q
• Descriptor: Tankyrase-2, ZINC ION, 4-{2-[(6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-yl)amino]ethyl}phenol, ... (5 entities in total)
• Functional Keywords: diphtheria toxin like adp-ribose transferase domain, poly adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 55653.20

Authors

Karlberg, T.,Camaioni, E.,Schuler, H. (deposition date: 2013-08-12, release date: 2014-03-12, Last modification date: 2023-09-20)

• Primary citation: Liscio, P.,Carotti, A.,Asciutti, S.,Karlberg, T.,Bellocchi, D.,Llacuna, L.,Macchiarulo, A.,Aaronson, S.A.,Schuler, H.,Pellicciari, R.,Camaioni, E.; Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors.; J.Med.Chem., 57:2807-2812, 2014; PubMed: 24527792; DOI: 10.1021/jm401356t

Experimental method

X-RAY DIFFRACTION (1.95 Å)