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9CKV
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Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G.
Deposit date:2024-07-09
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:De Novo Design of Integrin alpha5beta1 Modulating Proteins for Regenerative Medicine
To Be Published
8T2V
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Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
Deposit date:2023-06-06
Release date:2023-07-26
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
8T2U
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Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
Deposit date:2023-06-06
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
8IJ5
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Cryo-EM structure of Integrin AVB3
Descriptor: Integrin alpha-V heavy chain, Integrin beta-3
Authors:Xi, Z, Cang, W, Yuanzhu, G.
Deposit date:2023-02-26
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:cryo-EM Structure of Integrin AVB3
To Be Published
8GCE
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The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
8GCD
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Full length Integrin AlphaIIbBeta3 in inactive state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
7Y1T
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Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duan, Z, Zhang, Z.
Deposit date:2022-06-08
Release date:2022-08-31
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Nat Commun, 13, 2022
7USM
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BU of 7usm by Molmil
Integrin alphaM/beta2 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Goldsmith, J.A, McLellan, J.S.
Deposit date:2022-04-25
Release date:2022-08-17
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
7USL
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Integrin alphaM/beta2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goldsmith, J.A, McLellan, J.S.
Deposit date:2022-04-25
Release date:2022-08-17
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
7P2D
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BU of 7p2d by Molmil
Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Jensen, R.K, Andersen, G.R.
Deposit date:2021-07-05
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into the function-modulating effects of nanobody binding to the integrin receptor alpha M beta 2.
J.Biol.Chem., 298, 2022
7NXD
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BU of 7nxd by Molmil
Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
Deposit date:2021-03-18
Release date:2021-08-25
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
7NWL
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Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ...
Authors:Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
Deposit date:2021-03-17
Release date:2021-06-02
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
7LA4
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BU of 7la4 by Molmil
Integrin AlphaIIbBeta3-PT25-2 Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J.
Deposit date:2021-01-05
Release date:2022-01-12
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding.
Blood Adv, 5, 2021
7CEC
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BU of 7cec by Molmil
Structure of alpha6beta1 integrin in complex with laminin-511
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Arimori, T, Miyazaki, N, Takagi, J.
Deposit date:2020-06-22
Release date:2021-06-23
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism of laminin recognition by integrin.
Nat Commun, 12, 2021
7CEB
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BU of 7ceb by Molmil
Crystal structure of alpha6beta1 integrin headpiece
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-6, ...
Authors:Arimori, T, Takagi, J.
Deposit date:2020-06-22
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural mechanism of laminin recognition by integrin.
Nat Commun, 12, 2021
6V4P
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BU of 6v4p by Molmil
Structure of the integrin AlphaIIbBeta3-Abciximab complex
Descriptor: Abciximab, heavy chain, light chain, ...
Authors:Nesic, D, Zhang, Y, Spasic, A, Li, J, Provasi, D, Filizola, M, Walz, T, Coller, B.S.
Deposit date:2019-11-28
Release date:2020-02-05
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex.
Arterioscler Thromb Vasc Biol., 40, 2020
6UJC
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BU of 6ujc by Molmil
Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6-RGD3 heavy chain Fab, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6UJB
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Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6UJA
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Integrin alpha-v beta-8 in complex with pro-TGF-beta1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6OM2
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Crystal structure of atypical integrin alphaV beta8 with proTGF-beta1 ligand peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, J.C, Springer, T.A.
Deposit date:2019-04-17
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:General structural features that regulate integrin affinity revealed by atypical alpha V beta 8.
Nat Commun, 10, 2019
6OM1
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Crystal structure of an atypical integrin
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, J.C, Springer, T.A.
Deposit date:2019-04-17
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:General structural features that regulate integrin affinity revealed by atypical alpha V beta 8.
Nat Commun, 10, 2019
6NAJ
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Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-12-05
Release date:2019-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis.
Nat Commun, 11, 2020
6MSU
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BU of 6msu by Molmil
Integrin alphaVBeta3 in complex with EETI-II 2.5F
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:van Agthoven, J.F, Arnaout, M.A.
Deposit date:2018-10-18
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6MSL
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Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cystine Knot Protein 2.5D, ...
Authors:van Agthoven, J.F, Arnaout, M.A.
Deposit date:2018-10-16
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.104 Å)
Cite:Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6MK0
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Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161
Descriptor: (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-09-24
Release date:2019-09-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019

 

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