7NWL

Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp

Summary for 7NWL

• Entry DOI: 10.2210/pdb7nwl/pdb
• Related: 1fnf 3vi3 4wk0 5cxc 7NXD
• EMDB information: 12634
• Descriptor: Integrin alpha-5, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MANGANESE (II) ION, ... (11 entities in total)
• Functional Keywords: integrin, fibronectin, ts2/16, cell adhesion, plasma membrane protein, a5b1, alpha5beta1, focal adhesion, open conformation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 280943.50

Authors

Schumacher, S.,Dedden, D.,Vazquez Nunez, R.,Matoba, K.,Takagi, J.,Biertumpfel, C.,Mizuno, N. (deposition date: 2021-03-17, release date: 2021-06-02)

• Primary citation: Schumacher, S.,Dedden, D.,Nunez, R.V.,Matoba, K.,Takagi, J.,Biertumpfel, C.,Mizuno, N.; Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.; Sci Adv, 7:-, 2021; PubMed: 33962943; DOI: 10.1126/sciadv.abe9716

Experimental method

ELECTRON MICROSCOPY (3.1 Å)