Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8UIB
DownloadVisualize
BU of 8uib by Molmil
Structure of the human INTS9-INTS11-BRAT1 complex
Descriptor: BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ...
Authors:Lin, M, Tong, L.
Deposit date:2023-10-10
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
9F42
DownloadVisualize
BU of 9f42 by Molmil
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1, focused on RAPTOR
Descriptor: Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F43
DownloadVisualize
BU of 9f43 by Molmil
cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR
Descriptor: Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F44
DownloadVisualize
BU of 9f44 by Molmil
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1
Descriptor: INOSITOL HEXAKISPHOSPHATE, Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR, ...
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F45
DownloadVisualize
BU of 9f45 by Molmil
cryo-EM structure of human LST2 bound to human mTOR complex 1
Descriptor: INOSITOL HEXAKISPHOSPHATE, Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR, ...
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
8R23
DownloadVisualize
BU of 8r23 by Molmil
INTS9-INTS11-BRAT1 complex
Descriptor: BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ...
Authors:Sabath, K, Qiu, C, Jonas, S.
Deposit date:2023-11-02
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Assembly mechanism of Integrator's RNA cleavage module.
Mol.Cell, 84, 2024
8R2D
DownloadVisualize
BU of 8r2d by Molmil
Integrator cleavage module assembly intermediate
Descriptor: BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 4, ...
Authors:Sabath, K, Qiu, C, Jonas, S.
Deposit date:2023-11-03
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Assembly mechanism of Integrator's RNA cleavage module.
Mol.Cell, 84, 2024
8R22
DownloadVisualize
BU of 8r22 by Molmil
INTS9-INTS11-BRAT1-WDR73 complex
Descriptor: BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ...
Authors:Sabath, K, Qiu, C, Jonas, S.
Deposit date:2023-11-02
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Assembly mechanism of Integrator's RNA cleavage module.
Mol.Cell, 84, 2024
8RBX
DownloadVisualize
BU of 8rbx by Molmil
Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-05
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
8RC4
DownloadVisualize
BU of 8rc4 by Molmil
Structure of Integrator-PP2A complex
Descriptor: DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-06
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
8RBZ
DownloadVisualize
BU of 8rbz by Molmil
Structure of Integrator-PP2A-SOSS-CTD post-termination complex
Descriptor: DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-05
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
8U1X
DownloadVisualize
BU of 8u1x by Molmil
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Wu, C.G, Xing, Y.
Deposit date:2023-09-04
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U89
DownloadVisualize
BU of 8u89 by Molmil
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Wu, C.G, Xing, Y.
Deposit date:2023-09-16
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TWI
DownloadVisualize
BU of 8twi by Molmil
Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
Descriptor: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-08-21
Release date:2023-11-01
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8TWE
DownloadVisualize
BU of 8twe by Molmil
Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
Descriptor: PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-08-21
Release date:2023-11-01
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8TTB
DownloadVisualize
BU of 8ttb by Molmil
Cryo-EM structure of the PP2A:B55-ARPP19 complex
Descriptor: FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-08-13
Release date:2023-10-25
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8SO0
DownloadVisualize
BU of 8so0 by Molmil
Cryo-EM structure of the PP2A:B55-FAM122A complex
Descriptor: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-04-28
Release date:2023-10-25
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.79961 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
7XVK
DownloadVisualize
BU of 7xvk by Molmil
Modularity of Phytophthora effectors enables host mimicry of a principal phosphatase
Descriptor: 1,2-ETHANEDIOL, RxLR effector protein PSR2, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Authors:Wang, J, Wang, Y.
Deposit date:2022-05-24
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Pathogen protein modularity enables elaborate mimicry of a host phosphatase.
Cell, 186, 2023
8SGH
DownloadVisualize
BU of 8sgh by Molmil
Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1
Authors:Gonzalez, A, Fung, H.Y.J, Chook, Y.M.
Deposit date:2023-04-12
Release date:2023-06-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.
Structure, 31, 2023
7YCX
DownloadVisualize
BU of 7ycx by Molmil
The structure of INTAC-PEC complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y.
Deposit date:2022-07-02
Release date:2023-03-15
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
7PQH
DownloadVisualize
BU of 7pqh by Molmil
Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).
Descriptor: Serine/threonine-protein kinase TOR2, Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8
Authors:Felix, J, Prouteau, M, Bourgoint, C, Bonadei, L, Desfosses, A, Gabus, C, Sadian, Y, Savvides, S.N, Gutsche, I, Loewith, R.
Deposit date:2021-09-17
Release date:2023-01-18
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:EGOC inhibits TOROID polymerization by structurally activating TORC1.
Nat.Struct.Mol.Biol., 30, 2023
8ERA
DownloadVisualize
BU of 8era by Molmil
RMC-5552 in complex with mTORC1 and FKBP12
Descriptor: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Tomlinson, A.C.A, Yano, J.K.
Deposit date:2022-10-11
Release date:2022-12-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
7UXH
DownloadVisualize
BU of 7uxh by Molmil
cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Cui, Z, Hurley, J.
Deposit date:2022-05-05
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
7UX2
DownloadVisualize
BU of 7ux2 by Molmil
cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Cui, Z, Hurley, J.
Deposit date:2022-05-04
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
7UXC
DownloadVisualize
BU of 7uxc by Molmil
cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Cui, Z, Hurley, J.
Deposit date:2022-05-05
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023

 

1234>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon