7UXH

cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex

This is a non-PDB format compatible entry.

Summary for 7UXH

• Entry DOI: 10.2210/pdb7uxh/pdb
• Related: 7UXC
• EMDB information: 26852 26857 26861
• Descriptor: Serine/threonine-protein kinase mTOR, Ragulator complex protein LAMTOR5, Transcription factor EB, ... (15 entities in total)
• Functional Keywords: mtorc1, tfeb, lysosome biogenesis, autophagy, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 36
• Total formula weight: 1644644.58

Authors

Cui, Z.,Hurley, J. (deposition date: 2022-05-05, release date: 2022-11-30, Last modification date: 2023-03-01)

• Primary citation: Cui, Z.,Napolitano, G.,de Araujo, M.E.G.,Esposito, A.,Monfregola, J.,Huber, L.A.,Ballabio, A.,Hurley, J.H.; Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.; Nature, 614:572-579, 2023; PubMed: 36697823; DOI: 10.1038/s41586-022-05652-7

Experimental method

ELECTRON MICROSCOPY (3.2 Å)