7UXH

cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001002	molecular_function	RNA polymerase III type 1 promoter sequence-specific DNA binding
A	0001003	molecular_function	RNA polymerase III type 2 promoter sequence-specific DNA binding
A	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
A	0001156	molecular_function	TFIIIC-class transcription factor complex binding
A	0001558	biological_process	regulation of cell growth
A	0001932	biological_process	regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0002296	biological_process	T-helper 1 cell lineage commitment
A	0003007	biological_process	heart morphogenesis
A	0003179	biological_process	heart valve morphogenesis
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006112	biological_process	energy reserve metabolic process
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006468	biological_process	protein phosphorylation
A	0006954	biological_process	inflammatory response
A	0006974	biological_process	DNA damage response
A	0007010	biological_process	cytoskeleton organization
A	0007040	biological_process	lysosome organization
A	0007281	biological_process	germ cell development
A	0007584	biological_process	response to nutrient
A	0008361	biological_process	regulation of cell size
A	0009267	biological_process	cellular response to starvation
A	0009408	biological_process	response to heat
A	0009791	biological_process	post-embryonic development
A	0010506	biological_process	regulation of autophagy
A	0010507	biological_process	negative regulation of autophagy
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0010628	biological_process	positive regulation of gene expression
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0010831	biological_process	positive regulation of myotube differentiation
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0016236	biological_process	macroautophagy
A	0016241	biological_process	regulation of macroautophagy
A	0016242	biological_process	negative regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016605	cellular_component	PML body
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019228	biological_process	neuronal action potential
A	0030030	biological_process	cell projection organization
A	0030163	biological_process	protein catabolic process
A	0030307	biological_process	positive regulation of cell growth
A	0030425	cellular_component	dendrite
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0031295	biological_process	T cell costimulation
A	0031410	cellular_component	cytoplasmic vesicle
A	0031529	biological_process	ruffle organization
A	0031641	biological_process	regulation of myelination
A	0031648	biological_process	protein destabilization
A	0031667	biological_process	response to nutrient levels
A	0031669	biological_process	cellular response to nutrient levels
A	0031670	biological_process	cellular response to nutrient
A	0031929	biological_process	TOR signaling
A	0031931	cellular_component	TORC1 complex
A	0031932	cellular_component	TORC2 complex
A	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
A	0032868	biological_process	response to insulin
A	0032869	biological_process	cellular response to insulin stimulus
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0033173	biological_process	calcineurin-NFAT signaling cascade
A	0034198	biological_process	cellular response to amino acid starvation
A	0035264	biological_process	multicellular organism growth
A	0038202	biological_process	TORC1 signaling
A	0042752	biological_process	regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0043022	molecular_function	ribosome binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043200	biological_process	response to amino acid
A	0043276	biological_process	anoikis
A	0044877	molecular_function	protein-containing complex binding
A	0045335	cellular_component	phagocytic vesicle
A	0045670	biological_process	regulation of osteoclast differentiation
A	0045727	biological_process	positive regulation of translation
A	0045792	biological_process	negative regulation of cell size
A	0045821	biological_process	positive regulation of glycolytic process
A	0045945	biological_process	positive regulation of transcription by RNA polymerase III
A	0045948	biological_process	positive regulation of translational initiation
A	0046777	biological_process	protein autophosphorylation
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0048266	biological_process	behavioral response to pain
A	0048511	biological_process	rhythmic process
A	0048709	biological_process	oligodendrocyte differentiation
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0048738	biological_process	cardiac muscle tissue development
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0050882	biological_process	voluntary musculoskeletal movement
A	0051128	biological_process	regulation of cellular component organization
A	0051219	molecular_function	phosphoprotein binding
A	0051247	biological_process	positive regulation of protein metabolic process
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0051549	biological_process	positive regulation of keratinocyte migration
A	0051647	biological_process	nucleus localization
A	0051896	biological_process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0055006	biological_process	cardiac cell development
A	0055013	biological_process	cardiac muscle cell development
A	0060048	biological_process	cardiac muscle contraction
A	0061431	biological_process	cellular response to methionine
A	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071233	biological_process	cellular response to L-leucine
A	0071456	biological_process	cellular response to hypoxia
A	0071470	biological_process	cellular response to osmotic stress
A	0080135	biological_process	regulation of cellular response to stress
A	0090559	biological_process	regulation of membrane permeability
A	0106310	molecular_function	protein serine kinase activity
A	1900034	biological_process	regulation of cellular response to heat
A	1900181	biological_process	negative regulation of protein localization to nucleus
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A	1903691	biological_process	positive regulation of wound healing, spreading of epidermal cells
A	1904059	biological_process	regulation of locomotor rhythm
A	1904690	biological_process	positive regulation of cytoplasmic translational initiation
A	1905672	biological_process	negative regulation of lysosome organization
A	1905857	biological_process	positive regulation of pentose-phosphate shunt
A	1990253	biological_process	cellular response to leucine starvation
A	2000785	biological_process	regulation of autophagosome assembly
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0006974	biological_process	DNA damage response
B	0007010	biological_process	cytoskeleton organization
B	0010507	biological_process	negative regulation of autophagy
B	0016020	cellular_component	membrane
B	0030307	biological_process	positive regulation of cell growth
B	0030838	biological_process	positive regulation of actin filament polymerization
B	0031669	biological_process	cellular response to nutrient levels
B	0031929	biological_process	TOR signaling
B	0031931	cellular_component	TORC1 complex
B	0031932	cellular_component	TORC2 complex
B	0032008	biological_process	positive regulation of TOR signaling
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0038202	biological_process	TORC1 signaling
B	0043066	biological_process	negative regulation of apoptotic process
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0045821	biological_process	positive regulation of glycolytic process
B	0046889	biological_process	positive regulation of lipid biosynthetic process
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0071456	biological_process	cellular response to hypoxia
B	0071470	biological_process	cellular response to osmotic stress
B	1905857	biological_process	positive regulation of pentose-phosphate shunt
C	0000139	cellular_component	Golgi membrane
C	0001002	molecular_function	RNA polymerase III type 1 promoter sequence-specific DNA binding
C	0001003	molecular_function	RNA polymerase III type 2 promoter sequence-specific DNA binding
C	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
C	0001156	molecular_function	TFIIIC-class transcription factor complex binding
C	0001558	biological_process	regulation of cell growth
C	0001932	biological_process	regulation of protein phosphorylation
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002296	biological_process	T-helper 1 cell lineage commitment
C	0003007	biological_process	heart morphogenesis
C	0003179	biological_process	heart valve morphogenesis
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006112	biological_process	energy reserve metabolic process
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006468	biological_process	protein phosphorylation
C	0006954	biological_process	inflammatory response
C	0006974	biological_process	DNA damage response
C	0007010	biological_process	cytoskeleton organization
C	0007040	biological_process	lysosome organization
C	0007281	biological_process	germ cell development
C	0007584	biological_process	response to nutrient
C	0008361	biological_process	regulation of cell size
C	0009267	biological_process	cellular response to starvation
C	0009408	biological_process	response to heat
C	0009791	biological_process	post-embryonic development
C	0010506	biological_process	regulation of autophagy
C	0010507	biological_process	negative regulation of autophagy
C	0010592	biological_process	positive regulation of lamellipodium assembly
C	0010628	biological_process	positive regulation of gene expression
C	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
C	0010831	biological_process	positive regulation of myotube differentiation
C	0012505	cellular_component	endomembrane system
C	0016020	cellular_component	membrane
C	0016236	biological_process	macroautophagy
C	0016241	biological_process	regulation of macroautophagy
C	0016242	biological_process	negative regulation of macroautophagy
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016605	cellular_component	PML body
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0019228	biological_process	neuronal action potential
C	0030030	biological_process	cell projection organization
C	0030163	biological_process	protein catabolic process
C	0030307	biological_process	positive regulation of cell growth
C	0030425	cellular_component	dendrite
C	0030838	biological_process	positive regulation of actin filament polymerization
C	0031295	biological_process	T cell costimulation
C	0031410	cellular_component	cytoplasmic vesicle
C	0031529	biological_process	ruffle organization
C	0031641	biological_process	regulation of myelination
C	0031648	biological_process	protein destabilization
C	0031667	biological_process	response to nutrient levels
C	0031669	biological_process	cellular response to nutrient levels
C	0031670	biological_process	cellular response to nutrient
C	0031929	biological_process	TOR signaling
C	0031931	cellular_component	TORC1 complex
C	0031932	cellular_component	TORC2 complex
C	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
C	0032868	biological_process	response to insulin
C	0032869	biological_process	cellular response to insulin stimulus
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0033173	biological_process	calcineurin-NFAT signaling cascade
C	0034198	biological_process	cellular response to amino acid starvation
C	0035264	biological_process	multicellular organism growth
C	0038202	biological_process	TORC1 signaling
C	0042752	biological_process	regulation of circadian rhythm
C	0042802	molecular_function	identical protein binding
C	0043022	molecular_function	ribosome binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043200	biological_process	response to amino acid
C	0043276	biological_process	anoikis
C	0044877	molecular_function	protein-containing complex binding
C	0045335	cellular_component	phagocytic vesicle
C	0045670	biological_process	regulation of osteoclast differentiation
C	0045727	biological_process	positive regulation of translation
C	0045792	biological_process	negative regulation of cell size
C	0045821	biological_process	positive regulation of glycolytic process
C	0045945	biological_process	positive regulation of transcription by RNA polymerase III
C	0045948	biological_process	positive regulation of translational initiation
C	0046777	biological_process	protein autophosphorylation
C	0046889	biological_process	positive regulation of lipid biosynthetic process
C	0048266	biological_process	behavioral response to pain
C	0048511	biological_process	rhythmic process
C	0048709	biological_process	oligodendrocyte differentiation
C	0048714	biological_process	positive regulation of oligodendrocyte differentiation
C	0048738	biological_process	cardiac muscle tissue development
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0050882	biological_process	voluntary musculoskeletal movement
C	0051128	biological_process	regulation of cellular component organization
C	0051219	molecular_function	phosphoprotein binding
C	0051247	biological_process	positive regulation of protein metabolic process
C	0051496	biological_process	positive regulation of stress fiber assembly
C	0051549	biological_process	positive regulation of keratinocyte migration
C	0051647	biological_process	nucleus localization
C	0051896	biological_process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0055006	biological_process	cardiac cell development
C	0055013	biological_process	cardiac muscle cell development
C	0060048	biological_process	cardiac muscle contraction
C	0061431	biological_process	cellular response to methionine
C	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071233	biological_process	cellular response to L-leucine
C	0071456	biological_process	cellular response to hypoxia
C	0071470	biological_process	cellular response to osmotic stress
C	0080135	biological_process	regulation of cellular response to stress
C	0090559	biological_process	regulation of membrane permeability
C	0106310	molecular_function	protein serine kinase activity
C	1900034	biological_process	regulation of cellular response to heat
C	1900181	biological_process	negative regulation of protein localization to nucleus
C	1901796	biological_process	regulation of signal transduction by p53 class mediator
C	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
C	1903691	biological_process	positive regulation of wound healing, spreading of epidermal cells
C	1904059	biological_process	regulation of locomotor rhythm
C	1904690	biological_process	positive regulation of cytoplasmic translational initiation
C	1905672	biological_process	negative regulation of lysosome organization
C	1905857	biological_process	positive regulation of pentose-phosphate shunt
C	1990253	biological_process	cellular response to leucine starvation
C	2000785	biological_process	regulation of autophagosome assembly
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0005829	cellular_component	cytosol
D	0006974	biological_process	DNA damage response
D	0007010	biological_process	cytoskeleton organization
D	0010507	biological_process	negative regulation of autophagy
D	0016020	cellular_component	membrane
D	0030307	biological_process	positive regulation of cell growth
D	0030838	biological_process	positive regulation of actin filament polymerization
D	0031669	biological_process	cellular response to nutrient levels
D	0031929	biological_process	TOR signaling
D	0031931	cellular_component	TORC1 complex
D	0031932	cellular_component	TORC2 complex
D	0032008	biological_process	positive regulation of TOR signaling
D	0032956	biological_process	regulation of actin cytoskeleton organization
D	0038202	biological_process	TORC1 signaling
D	0043066	biological_process	negative regulation of apoptotic process
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0045821	biological_process	positive regulation of glycolytic process
D	0046889	biological_process	positive regulation of lipid biosynthetic process
D	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
D	0071456	biological_process	cellular response to hypoxia
D	0071470	biological_process	cellular response to osmotic stress
D	1905857	biological_process	positive regulation of pentose-phosphate shunt
E	0001558	biological_process	regulation of cell growth
E	0001938	biological_process	positive regulation of endothelial cell proliferation
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0006974	biological_process	DNA damage response
E	0008361	biological_process	regulation of cell size
E	0009267	biological_process	cellular response to starvation
E	0009410	biological_process	response to xenobiotic stimulus
E	0010494	cellular_component	cytoplasmic stress granule
E	0010506	biological_process	regulation of autophagy
E	0010507	biological_process	negative regulation of autophagy
E	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
E	0016020	cellular_component	membrane
E	0019901	molecular_function	protein kinase binding
E	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
E	0030295	molecular_function	protein kinase activator activity
E	0030307	biological_process	positive regulation of cell growth
E	0030425	cellular_component	dendrite
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031267	molecular_function	small GTPase binding
E	0031669	biological_process	cellular response to nutrient levels
E	0031929	biological_process	TOR signaling
E	0031931	cellular_component	TORC1 complex
E	0032008	biological_process	positive regulation of TOR signaling
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0035176	biological_process	social behavior
E	0038202	biological_process	TORC1 signaling
E	0042325	biological_process	regulation of phosphorylation
E	0043025	cellular_component	neuronal cell body
E	0044877	molecular_function	protein-containing complex binding
E	0045672	biological_process	positive regulation of osteoclast differentiation
E	0045821	biological_process	positive regulation of glycolytic process
E	0045945	biological_process	positive regulation of transcription by RNA polymerase III
E	0046889	biological_process	positive regulation of lipid biosynthetic process
E	0071230	biological_process	cellular response to amino acid stimulus
E	0071233	biological_process	cellular response to L-leucine
E	0071333	biological_process	cellular response to glucose stimulus
E	0071456	biological_process	cellular response to hypoxia
E	0071470	biological_process	cellular response to osmotic stress
E	0071889	molecular_function	14-3-3 protein binding
E	0140767	molecular_function	enzyme-substrate adaptor activity
E	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
E	1901331	biological_process	positive regulation of odontoblast differentiation
E	1905857	biological_process	positive regulation of pentose-phosphate shunt
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0005829	cellular_component	cytosol
F	0006915	biological_process	apoptotic process
F	0008104	biological_process	protein localization
F	0009267	biological_process	cellular response to starvation
F	0010507	biological_process	negative regulation of autophagy
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031669	biological_process	cellular response to nutrient levels
F	0032008	biological_process	positive regulation of TOR signaling
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0034198	biological_process	cellular response to amino acid starvation
F	0035556	biological_process	intracellular signal transduction
F	0042593	biological_process	glucose homeostasis
F	0042803	molecular_function	protein homodimerization activity
F	0043495	molecular_function	protein-membrane adaptor activity
F	0046982	molecular_function	protein heterodimerization activity
F	0051219	molecular_function	phosphoprotein binding
F	0061462	biological_process	protein localization to lysosome
F	0071230	biological_process	cellular response to amino acid stimulus
F	0072657	biological_process	protein localization to membrane
F	1904263	biological_process	positive regulation of TORC1 signaling
F	1990130	cellular_component	GATOR1 complex
F	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
F	1990877	cellular_component	FNIP-folliculin RagC/D GAP
G	0000287	molecular_function	magnesium ion binding
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0006351	biological_process	DNA-templated transcription
G	0006915	biological_process	apoptotic process
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0008104	biological_process	protein localization
G	0008380	biological_process	RNA splicing
G	0009267	biological_process	cellular response to starvation
G	0010507	biological_process	negative regulation of autophagy
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0019003	molecular_function	GDP binding
G	0031669	biological_process	cellular response to nutrient levels
G	0032006	biological_process	regulation of TOR signaling
G	0034198	biological_process	cellular response to amino acid starvation
G	0043200	biological_process	response to amino acid
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0043495	molecular_function	protein-membrane adaptor activity
G	0046982	molecular_function	protein heterodimerization activity
G	0051020	molecular_function	GTPase binding
G	0060090	molecular_function	molecular adaptor activity
G	0061462	biological_process	protein localization to lysosome
G	0071230	biological_process	cellular response to amino acid stimulus
G	0072657	biological_process	protein localization to membrane
G	0140767	molecular_function	enzyme-substrate adaptor activity
G	1903432	biological_process	regulation of TORC1 signaling
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
G	1990877	cellular_component	FNIP-folliculin RagC/D GAP
H	0001558	biological_process	regulation of cell growth
H	0001919	biological_process	regulation of receptor recycling
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005764	cellular_component	lysosome
H	0005765	cellular_component	lysosomal membrane
H	0005768	cellular_component	endosome
H	0005886	cellular_component	plasma membrane
H	0007032	biological_process	endosome organization
H	0007040	biological_process	lysosome organization
H	0008104	biological_process	protein localization
H	0010874	biological_process	regulation of cholesterol efflux
H	0016020	cellular_component	membrane
H	0016197	biological_process	endosomal transport
H	0031669	biological_process	cellular response to nutrient levels
H	0031902	cellular_component	late endosome membrane
H	0032008	biological_process	positive regulation of TOR signaling
H	0032418	biological_process	lysosome localization
H	0035577	cellular_component	azurophil granule membrane
H	0035579	cellular_component	specific granule membrane
H	0038202	biological_process	TORC1 signaling
H	0042632	biological_process	cholesterol homeostasis
H	0043410	biological_process	positive regulation of MAPK cascade
H	0043495	molecular_function	protein-membrane adaptor activity
H	0045121	cellular_component	membrane raft
H	0051020	molecular_function	GTPase binding
H	0060090	molecular_function	molecular adaptor activity
H	0060620	biological_process	regulation of cholesterol import
H	0070062	cellular_component	extracellular exosome
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
H	0072657	biological_process	protein localization to membrane
H	0101003	cellular_component	ficolin-1-rich granule membrane
H	0150032	biological_process	positive regulation of protein localization to lysosome
H	1904263	biological_process	positive regulation of TORC1 signaling
H	1990877	cellular_component	FNIP-folliculin RagC/D GAP
I	0001558	biological_process	regulation of cell growth
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005764	cellular_component	lysosome
I	0005765	cellular_component	lysosomal membrane
I	0005768	cellular_component	endosome
I	0005770	cellular_component	late endosome
I	0005886	cellular_component	plasma membrane
I	0008104	biological_process	protein localization
I	0010008	cellular_component	endosome membrane
I	0010761	biological_process	fibroblast migration
I	0016020	cellular_component	membrane
I	0031902	cellular_component	late endosome membrane
I	0032008	biological_process	positive regulation of TOR signaling
I	0035579	cellular_component	specific granule membrane
I	0038202	biological_process	TORC1 signaling
I	0043410	biological_process	positive regulation of MAPK cascade
I	0060090	molecular_function	molecular adaptor activity
I	0070821	cellular_component	tertiary granule membrane
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071986	cellular_component	Ragulator complex
I	0150116	biological_process	regulation of cell-substrate junction organization
I	1902414	biological_process	protein localization to cell junction
I	1904263	biological_process	positive regulation of TORC1 signaling
I	1990877	cellular_component	FNIP-folliculin RagC/D GAP
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005765	cellular_component	lysosomal membrane
J	0005768	cellular_component	endosome
J	0005770	cellular_component	late endosome
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0008104	biological_process	protein localization
J	0010008	cellular_component	endosome membrane
J	0016020	cellular_component	membrane
J	0019209	molecular_function	kinase activator activity
J	0031902	cellular_component	late endosome membrane
J	0032006	biological_process	regulation of TOR signaling
J	0032008	biological_process	positive regulation of TOR signaling
J	0035579	cellular_component	specific granule membrane
J	0038202	biological_process	TORC1 signaling
J	0043410	biological_process	positive regulation of MAPK cascade
J	0060090	molecular_function	molecular adaptor activity
J	0070062	cellular_component	extracellular exosome
J	0070821	cellular_component	tertiary granule membrane
J	0071230	biological_process	cellular response to amino acid stimulus
J	0071986	cellular_component	Ragulator complex
J	1902414	biological_process	protein localization to cell junction
J	1904263	biological_process	positive regulation of TORC1 signaling
J	1990877	cellular_component	FNIP-folliculin RagC/D GAP
K	0005085	molecular_function	guanyl-nucleotide exchange factor activity
K	0005515	molecular_function	protein binding
K	0005764	cellular_component	lysosome
K	0005765	cellular_component	lysosomal membrane
K	0008361	biological_process	regulation of cell size
K	0031902	cellular_component	late endosome membrane
K	0032008	biological_process	positive regulation of TOR signaling
K	0038202	biological_process	TORC1 signaling
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0060090	molecular_function	molecular adaptor activity
K	0061462	biological_process	protein localization to lysosome
K	0071230	biological_process	cellular response to amino acid stimulus
K	0071986	cellular_component	Ragulator complex
K	1904263	biological_process	positive regulation of TORC1 signaling
K	1990877	cellular_component	FNIP-folliculin RagC/D GAP
L	0005085	molecular_function	guanyl-nucleotide exchange factor activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005765	cellular_component	lysosomal membrane
L	0005829	cellular_component	cytosol
L	0008361	biological_process	regulation of cell size
L	0009615	biological_process	response to virus
L	0010628	biological_process	positive regulation of gene expression
L	0019079	biological_process	viral genome replication
L	0031902	cellular_component	late endosome membrane
L	0032008	biological_process	positive regulation of TOR signaling
L	0032757	biological_process	positive regulation of interleukin-8 production
L	0032991	cellular_component	protein-containing complex
L	0038202	biological_process	TORC1 signaling
L	0043066	biological_process	negative regulation of apoptotic process
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
L	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
L	0060090	molecular_function	molecular adaptor activity
L	0061462	biological_process	protein localization to lysosome
L	0071230	biological_process	cellular response to amino acid stimulus
L	0071986	cellular_component	Ragulator complex
L	1900182	biological_process	positive regulation of protein localization to nucleus
L	1904263	biological_process	positive regulation of TORC1 signaling
L	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
L	1990877	cellular_component	FNIP-folliculin RagC/D GAP
M	0003924	molecular_function	GTPase activity
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005765	cellular_component	lysosomal membrane
M	0005829	cellular_component	cytosol
M	0006915	biological_process	apoptotic process
M	0008104	biological_process	protein localization
M	0009267	biological_process	cellular response to starvation
M	0010507	biological_process	negative regulation of autophagy
M	0016020	cellular_component	membrane
M	0016787	molecular_function	hydrolase activity
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0031669	biological_process	cellular response to nutrient levels
M	0032008	biological_process	positive regulation of TOR signaling
M	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
M	0034198	biological_process	cellular response to amino acid starvation
M	0035556	biological_process	intracellular signal transduction
M	0042593	biological_process	glucose homeostasis
M	0042803	molecular_function	protein homodimerization activity
M	0043495	molecular_function	protein-membrane adaptor activity
M	0046982	molecular_function	protein heterodimerization activity
M	0051219	molecular_function	phosphoprotein binding
M	0061462	biological_process	protein localization to lysosome
M	0071230	biological_process	cellular response to amino acid stimulus
M	0072657	biological_process	protein localization to membrane
M	1904263	biological_process	positive regulation of TORC1 signaling
M	1990130	cellular_component	GATOR1 complex
M	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
M	1990877	cellular_component	FNIP-folliculin RagC/D GAP
N	0000287	molecular_function	magnesium ion binding
N	0003924	molecular_function	GTPase activity
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005765	cellular_component	lysosomal membrane
N	0005829	cellular_component	cytosol
N	0006351	biological_process	DNA-templated transcription
N	0006915	biological_process	apoptotic process
N	0007264	biological_process	small GTPase-mediated signal transduction
N	0008104	biological_process	protein localization
N	0008380	biological_process	RNA splicing
N	0009267	biological_process	cellular response to starvation
N	0010507	biological_process	negative regulation of autophagy
N	0016020	cellular_component	membrane
N	0016787	molecular_function	hydrolase activity
N	0019003	molecular_function	GDP binding
N	0031669	biological_process	cellular response to nutrient levels
N	0032006	biological_process	regulation of TOR signaling
N	0034198	biological_process	cellular response to amino acid starvation
N	0043200	biological_process	response to amino acid
N	0043231	cellular_component	intracellular membrane-bounded organelle
N	0043495	molecular_function	protein-membrane adaptor activity
N	0046982	molecular_function	protein heterodimerization activity
N	0051020	molecular_function	GTPase binding
N	0060090	molecular_function	molecular adaptor activity
N	0061462	biological_process	protein localization to lysosome
N	0071230	biological_process	cellular response to amino acid stimulus
N	0072657	biological_process	protein localization to membrane
N	0140767	molecular_function	enzyme-substrate adaptor activity
N	1903432	biological_process	regulation of TORC1 signaling
N	1904263	biological_process	positive regulation of TORC1 signaling
N	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
N	1990877	cellular_component	FNIP-folliculin RagC/D GAP
O	0001558	biological_process	regulation of cell growth
O	0001919	biological_process	regulation of receptor recycling
O	0005085	molecular_function	guanyl-nucleotide exchange factor activity
O	0005515	molecular_function	protein binding
O	0005764	cellular_component	lysosome
O	0005765	cellular_component	lysosomal membrane
O	0005768	cellular_component	endosome
O	0005886	cellular_component	plasma membrane
O	0007032	biological_process	endosome organization
O	0007040	biological_process	lysosome organization
O	0008104	biological_process	protein localization
O	0010874	biological_process	regulation of cholesterol efflux
O	0016020	cellular_component	membrane
O	0016197	biological_process	endosomal transport
O	0031669	biological_process	cellular response to nutrient levels
O	0031902	cellular_component	late endosome membrane
O	0032008	biological_process	positive regulation of TOR signaling
O	0032418	biological_process	lysosome localization
O	0035577	cellular_component	azurophil granule membrane
O	0035579	cellular_component	specific granule membrane
O	0038202	biological_process	TORC1 signaling
O	0042632	biological_process	cholesterol homeostasis
O	0043410	biological_process	positive regulation of MAPK cascade
O	0043495	molecular_function	protein-membrane adaptor activity
O	0045121	cellular_component	membrane raft
O	0051020	molecular_function	GTPase binding
O	0060090	molecular_function	molecular adaptor activity
O	0060620	biological_process	regulation of cholesterol import
O	0070062	cellular_component	extracellular exosome
O	0071230	biological_process	cellular response to amino acid stimulus
O	0071986	cellular_component	Ragulator complex
O	0072657	biological_process	protein localization to membrane
O	0101003	cellular_component	ficolin-1-rich granule membrane
O	0150032	biological_process	positive regulation of protein localization to lysosome
O	1904263	biological_process	positive regulation of TORC1 signaling
O	1990877	cellular_component	FNIP-folliculin RagC/D GAP
P	0001558	biological_process	regulation of cell growth
P	0005085	molecular_function	guanyl-nucleotide exchange factor activity
P	0005515	molecular_function	protein binding
P	0005764	cellular_component	lysosome
P	0005765	cellular_component	lysosomal membrane
P	0005768	cellular_component	endosome
P	0005770	cellular_component	late endosome
P	0005886	cellular_component	plasma membrane
P	0008104	biological_process	protein localization
P	0010008	cellular_component	endosome membrane
P	0010761	biological_process	fibroblast migration
P	0016020	cellular_component	membrane
P	0031902	cellular_component	late endosome membrane
P	0032008	biological_process	positive regulation of TOR signaling
P	0035579	cellular_component	specific granule membrane
P	0038202	biological_process	TORC1 signaling
P	0043410	biological_process	positive regulation of MAPK cascade
P	0060090	molecular_function	molecular adaptor activity
P	0070821	cellular_component	tertiary granule membrane
P	0071230	biological_process	cellular response to amino acid stimulus
P	0071986	cellular_component	Ragulator complex
P	0150116	biological_process	regulation of cell-substrate junction organization
P	1902414	biological_process	protein localization to cell junction
P	1904263	biological_process	positive regulation of TORC1 signaling
P	1990877	cellular_component	FNIP-folliculin RagC/D GAP
Q	0005085	molecular_function	guanyl-nucleotide exchange factor activity
Q	0005515	molecular_function	protein binding
Q	0005765	cellular_component	lysosomal membrane
Q	0005768	cellular_component	endosome
Q	0005770	cellular_component	late endosome
Q	0005886	cellular_component	plasma membrane
Q	0005925	cellular_component	focal adhesion
Q	0008104	biological_process	protein localization
Q	0010008	cellular_component	endosome membrane
Q	0016020	cellular_component	membrane
Q	0019209	molecular_function	kinase activator activity
Q	0031902	cellular_component	late endosome membrane
Q	0032006	biological_process	regulation of TOR signaling
Q	0032008	biological_process	positive regulation of TOR signaling
Q	0035579	cellular_component	specific granule membrane
Q	0038202	biological_process	TORC1 signaling
Q	0043410	biological_process	positive regulation of MAPK cascade
Q	0060090	molecular_function	molecular adaptor activity
Q	0070062	cellular_component	extracellular exosome
Q	0070821	cellular_component	tertiary granule membrane
Q	0071230	biological_process	cellular response to amino acid stimulus
Q	0071986	cellular_component	Ragulator complex
Q	1902414	biological_process	protein localization to cell junction
Q	1904263	biological_process	positive regulation of TORC1 signaling
Q	1990877	cellular_component	FNIP-folliculin RagC/D GAP
R	0005085	molecular_function	guanyl-nucleotide exchange factor activity
R	0005515	molecular_function	protein binding
R	0005764	cellular_component	lysosome
R	0005765	cellular_component	lysosomal membrane
R	0008361	biological_process	regulation of cell size
R	0031902	cellular_component	late endosome membrane
R	0032008	biological_process	positive regulation of TOR signaling
R	0038202	biological_process	TORC1 signaling
R	0043231	cellular_component	intracellular membrane-bounded organelle
R	0060090	molecular_function	molecular adaptor activity
R	0061462	biological_process	protein localization to lysosome
R	0071230	biological_process	cellular response to amino acid stimulus
R	0071986	cellular_component	Ragulator complex
R	1904263	biological_process	positive regulation of TORC1 signaling
R	1990877	cellular_component	FNIP-folliculin RagC/D GAP
S	0005085	molecular_function	guanyl-nucleotide exchange factor activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005764	cellular_component	lysosome
S	0005765	cellular_component	lysosomal membrane
S	0005829	cellular_component	cytosol
S	0008361	biological_process	regulation of cell size
S	0009615	biological_process	response to virus
S	0010628	biological_process	positive regulation of gene expression
S	0019079	biological_process	viral genome replication
S	0031902	cellular_component	late endosome membrane
S	0032008	biological_process	positive regulation of TOR signaling
S	0032757	biological_process	positive regulation of interleukin-8 production
S	0032991	cellular_component	protein-containing complex
S	0038202	biological_process	TORC1 signaling
S	0043066	biological_process	negative regulation of apoptotic process
S	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
S	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
S	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
S	0060090	molecular_function	molecular adaptor activity
S	0061462	biological_process	protein localization to lysosome
S	0071230	biological_process	cellular response to amino acid stimulus
S	0071986	cellular_component	Ragulator complex
S	1900182	biological_process	positive regulation of protein localization to nucleus
S	1904263	biological_process	positive regulation of TORC1 signaling
S	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
S	1990877	cellular_component	FNIP-folliculin RagC/D GAP
T	0000785	cellular_component	chromatin
T	0000976	molecular_function	transcription cis-regulatory region binding
T	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
T	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
T	0001892	biological_process	embryonic placenta development
T	0002250	biological_process	adaptive immune response
T	0003677	molecular_function	DNA binding
T	0003700	molecular_function	DNA-binding transcription factor activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005764	cellular_component	lysosome
T	0005765	cellular_component	lysosomal membrane
T	0005829	cellular_component	cytosol
T	0006355	biological_process	regulation of DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006914	biological_process	autophagy
T	0006959	biological_process	humoral immune response
T	0007040	biological_process	lysosome organization
T	0009267	biological_process	cellular response to starvation
T	0010508	biological_process	positive regulation of autophagy
T	0016020	cellular_component	membrane
T	0019899	molecular_function	enzyme binding
T	0032418	biological_process	lysosome localization
T	0034198	biological_process	cellular response to amino acid starvation
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0046983	molecular_function	protein dimerization activity
T	0061406	biological_process	obsolete positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
T	0140367	biological_process	antibacterial innate immune response
T	1990837	molecular_function	sequence-specific double-stranded DNA binding
U	0001558	biological_process	regulation of cell growth
U	0001938	biological_process	positive regulation of endothelial cell proliferation
U	0005515	molecular_function	protein binding
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005764	cellular_component	lysosome
U	0005765	cellular_component	lysosomal membrane
U	0005829	cellular_component	cytosol
U	0006974	biological_process	DNA damage response
U	0008361	biological_process	regulation of cell size
U	0009267	biological_process	cellular response to starvation
U	0009410	biological_process	response to xenobiotic stimulus
U	0010494	cellular_component	cytoplasmic stress granule
U	0010506	biological_process	regulation of autophagy
U	0010507	biological_process	negative regulation of autophagy
U	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
U	0016020	cellular_component	membrane
U	0019901	molecular_function	protein kinase binding
U	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
U	0030295	molecular_function	protein kinase activator activity
U	0030307	biological_process	positive regulation of cell growth
U	0030425	cellular_component	dendrite
U	0030674	molecular_function	protein-macromolecule adaptor activity
U	0031267	molecular_function	small GTPase binding
U	0031669	biological_process	cellular response to nutrient levels
U	0031929	biological_process	TOR signaling
U	0031931	cellular_component	TORC1 complex
U	0032008	biological_process	positive regulation of TOR signaling
U	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
U	0035176	biological_process	social behavior
U	0038202	biological_process	TORC1 signaling
U	0042325	biological_process	regulation of phosphorylation
U	0043025	cellular_component	neuronal cell body
U	0044877	molecular_function	protein-containing complex binding
U	0045672	biological_process	positive regulation of osteoclast differentiation
U	0045821	biological_process	positive regulation of glycolytic process
U	0045945	biological_process	positive regulation of transcription by RNA polymerase III
U	0046889	biological_process	positive regulation of lipid biosynthetic process
U	0071230	biological_process	cellular response to amino acid stimulus
U	0071233	biological_process	cellular response to L-leucine
U	0071333	biological_process	cellular response to glucose stimulus
U	0071456	biological_process	cellular response to hypoxia
U	0071470	biological_process	cellular response to osmotic stress
U	0071889	molecular_function	14-3-3 protein binding
U	0140767	molecular_function	enzyme-substrate adaptor activity
U	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
U	1901331	biological_process	positive regulation of odontoblast differentiation
U	1905857	biological_process	positive regulation of pentose-phosphate shunt
V	0003924	molecular_function	GTPase activity
V	0005515	molecular_function	protein binding
V	0005525	molecular_function	GTP binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005764	cellular_component	lysosome
V	0005765	cellular_component	lysosomal membrane
V	0005829	cellular_component	cytosol
V	0006915	biological_process	apoptotic process
V	0008104	biological_process	protein localization
V	0009267	biological_process	cellular response to starvation
V	0010507	biological_process	negative regulation of autophagy
V	0016020	cellular_component	membrane
V	0016787	molecular_function	hydrolase activity
V	0031625	molecular_function	ubiquitin protein ligase binding
V	0031669	biological_process	cellular response to nutrient levels
V	0032008	biological_process	positive regulation of TOR signaling
V	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
V	0034198	biological_process	cellular response to amino acid starvation
V	0035556	biological_process	intracellular signal transduction
V	0042593	biological_process	glucose homeostasis
V	0042803	molecular_function	protein homodimerization activity
V	0043495	molecular_function	protein-membrane adaptor activity
V	0046982	molecular_function	protein heterodimerization activity
V	0051219	molecular_function	phosphoprotein binding
V	0061462	biological_process	protein localization to lysosome
V	0071230	biological_process	cellular response to amino acid stimulus
V	0072657	biological_process	protein localization to membrane
V	1904263	biological_process	positive regulation of TORC1 signaling
V	1990130	cellular_component	GATOR1 complex
V	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
V	1990877	cellular_component	FNIP-folliculin RagC/D GAP
W	0000287	molecular_function	magnesium ion binding
W	0003924	molecular_function	GTPase activity
W	0005515	molecular_function	protein binding
W	0005525	molecular_function	GTP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005764	cellular_component	lysosome
W	0005765	cellular_component	lysosomal membrane
W	0005829	cellular_component	cytosol
W	0006351	biological_process	DNA-templated transcription
W	0006915	biological_process	apoptotic process
W	0007264	biological_process	small GTPase-mediated signal transduction
W	0008104	biological_process	protein localization
W	0008380	biological_process	RNA splicing
W	0009267	biological_process	cellular response to starvation
W	0010507	biological_process	negative regulation of autophagy
W	0016020	cellular_component	membrane
W	0016787	molecular_function	hydrolase activity
W	0019003	molecular_function	GDP binding
W	0031669	biological_process	cellular response to nutrient levels
W	0032006	biological_process	regulation of TOR signaling
W	0034198	biological_process	cellular response to amino acid starvation
W	0043200	biological_process	response to amino acid
W	0043231	cellular_component	intracellular membrane-bounded organelle
W	0043495	molecular_function	protein-membrane adaptor activity
W	0046982	molecular_function	protein heterodimerization activity
W	0051020	molecular_function	GTPase binding
W	0060090	molecular_function	molecular adaptor activity
W	0061462	biological_process	protein localization to lysosome
W	0071230	biological_process	cellular response to amino acid stimulus
W	0072657	biological_process	protein localization to membrane
W	0140767	molecular_function	enzyme-substrate adaptor activity
W	1903432	biological_process	regulation of TORC1 signaling
W	1904263	biological_process	positive regulation of TORC1 signaling
W	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
W	1990877	cellular_component	FNIP-folliculin RagC/D GAP
X	0001558	biological_process	regulation of cell growth
X	0001919	biological_process	regulation of receptor recycling
X	0005085	molecular_function	guanyl-nucleotide exchange factor activity
X	0005515	molecular_function	protein binding
X	0005764	cellular_component	lysosome
X	0005765	cellular_component	lysosomal membrane
X	0005768	cellular_component	endosome
X	0005886	cellular_component	plasma membrane
X	0007032	biological_process	endosome organization
X	0007040	biological_process	lysosome organization
X	0008104	biological_process	protein localization
X	0010874	biological_process	regulation of cholesterol efflux
X	0016020	cellular_component	membrane
X	0016197	biological_process	endosomal transport
X	0031669	biological_process	cellular response to nutrient levels
X	0031902	cellular_component	late endosome membrane
X	0032008	biological_process	positive regulation of TOR signaling
X	0032418	biological_process	lysosome localization
X	0035577	cellular_component	azurophil granule membrane
X	0035579	cellular_component	specific granule membrane
X	0038202	biological_process	TORC1 signaling
X	0042632	biological_process	cholesterol homeostasis
X	0043410	biological_process	positive regulation of MAPK cascade
X	0043495	molecular_function	protein-membrane adaptor activity
X	0045121	cellular_component	membrane raft
X	0051020	molecular_function	GTPase binding
X	0060090	molecular_function	molecular adaptor activity
X	0060620	biological_process	regulation of cholesterol import
X	0070062	cellular_component	extracellular exosome
X	0071230	biological_process	cellular response to amino acid stimulus
X	0071986	cellular_component	Ragulator complex
X	0072657	biological_process	protein localization to membrane
X	0101003	cellular_component	ficolin-1-rich granule membrane
X	0150032	biological_process	positive regulation of protein localization to lysosome
X	1904263	biological_process	positive regulation of TORC1 signaling
X	1990877	cellular_component	FNIP-folliculin RagC/D GAP
Y	0001558	biological_process	regulation of cell growth
Y	0005085	molecular_function	guanyl-nucleotide exchange factor activity
Y	0005515	molecular_function	protein binding
Y	0005764	cellular_component	lysosome
Y	0005765	cellular_component	lysosomal membrane
Y	0005768	cellular_component	endosome
Y	0005770	cellular_component	late endosome
Y	0005886	cellular_component	plasma membrane
Y	0008104	biological_process	protein localization
Y	0010008	cellular_component	endosome membrane
Y	0010761	biological_process	fibroblast migration
Y	0016020	cellular_component	membrane
Y	0031902	cellular_component	late endosome membrane
Y	0032008	biological_process	positive regulation of TOR signaling
Y	0035579	cellular_component	specific granule membrane
Y	0038202	biological_process	TORC1 signaling
Y	0043410	biological_process	positive regulation of MAPK cascade
Y	0060090	molecular_function	molecular adaptor activity
Y	0070821	cellular_component	tertiary granule membrane
Y	0071230	biological_process	cellular response to amino acid stimulus
Y	0071986	cellular_component	Ragulator complex
Y	0150116	biological_process	regulation of cell-substrate junction organization
Y	1902414	biological_process	protein localization to cell junction
Y	1904263	biological_process	positive regulation of TORC1 signaling
Y	1990877	cellular_component	FNIP-folliculin RagC/D GAP
Z	0005085	molecular_function	guanyl-nucleotide exchange factor activity
Z	0005515	molecular_function	protein binding
Z	0005765	cellular_component	lysosomal membrane
Z	0005768	cellular_component	endosome
Z	0005770	cellular_component	late endosome
Z	0005886	cellular_component	plasma membrane
Z	0005925	cellular_component	focal adhesion
Z	0008104	biological_process	protein localization
Z	0010008	cellular_component	endosome membrane
Z	0016020	cellular_component	membrane
Z	0019209	molecular_function	kinase activator activity
Z	0031902	cellular_component	late endosome membrane
Z	0032006	biological_process	regulation of TOR signaling
Z	0032008	biological_process	positive regulation of TOR signaling
Z	0035579	cellular_component	specific granule membrane
Z	0038202	biological_process	TORC1 signaling
Z	0043410	biological_process	positive regulation of MAPK cascade
Z	0060090	molecular_function	molecular adaptor activity
Z	0070062	cellular_component	extracellular exosome
Z	0070821	cellular_component	tertiary granule membrane
Z	0071230	biological_process	cellular response to amino acid stimulus
Z	0071986	cellular_component	Ragulator complex
Z	1902414	biological_process	protein localization to cell junction
Z	1904263	biological_process	positive regulation of TORC1 signaling
Z	1990877	cellular_component	FNIP-folliculin RagC/D GAP
a	0005085	molecular_function	guanyl-nucleotide exchange factor activity
a	0005515	molecular_function	protein binding
a	0005764	cellular_component	lysosome
a	0005765	cellular_component	lysosomal membrane
a	0008361	biological_process	regulation of cell size
a	0031902	cellular_component	late endosome membrane
a	0032008	biological_process	positive regulation of TOR signaling
a	0038202	biological_process	TORC1 signaling
a	0043231	cellular_component	intracellular membrane-bounded organelle
a	0060090	molecular_function	molecular adaptor activity
a	0061462	biological_process	protein localization to lysosome
a	0071230	biological_process	cellular response to amino acid stimulus
a	0071986	cellular_component	Ragulator complex
a	1904263	biological_process	positive regulation of TORC1 signaling
a	1990877	cellular_component	FNIP-folliculin RagC/D GAP
b	0005085	molecular_function	guanyl-nucleotide exchange factor activity
b	0005515	molecular_function	protein binding
b	0005737	cellular_component	cytoplasm
b	0005764	cellular_component	lysosome
b	0005765	cellular_component	lysosomal membrane
b	0005829	cellular_component	cytosol
b	0008361	biological_process	regulation of cell size
b	0009615	biological_process	response to virus
b	0010628	biological_process	positive regulation of gene expression
b	0019079	biological_process	viral genome replication
b	0031902	cellular_component	late endosome membrane
b	0032008	biological_process	positive regulation of TOR signaling
b	0032757	biological_process	positive regulation of interleukin-8 production
b	0032991	cellular_component	protein-containing complex
b	0038202	biological_process	TORC1 signaling
b	0043066	biological_process	negative regulation of apoptotic process
b	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
b	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
b	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
b	0060090	molecular_function	molecular adaptor activity
b	0061462	biological_process	protein localization to lysosome
b	0071230	biological_process	cellular response to amino acid stimulus
b	0071986	cellular_component	Ragulator complex
b	1900182	biological_process	positive regulation of protein localization to nucleus
b	1904263	biological_process	positive regulation of TORC1 signaling
b	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
b	1990877	cellular_component	FNIP-folliculin RagC/D GAP
c	0003924	molecular_function	GTPase activity
c	0005515	molecular_function	protein binding
c	0005525	molecular_function	GTP binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005764	cellular_component	lysosome
c	0005765	cellular_component	lysosomal membrane
c	0005829	cellular_component	cytosol
c	0006915	biological_process	apoptotic process
c	0008104	biological_process	protein localization
c	0009267	biological_process	cellular response to starvation
c	0010507	biological_process	negative regulation of autophagy
c	0016020	cellular_component	membrane
c	0016787	molecular_function	hydrolase activity
c	0031625	molecular_function	ubiquitin protein ligase binding
c	0031669	biological_process	cellular response to nutrient levels
c	0032008	biological_process	positive regulation of TOR signaling
c	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
c	0034198	biological_process	cellular response to amino acid starvation
c	0035556	biological_process	intracellular signal transduction
c	0042593	biological_process	glucose homeostasis
c	0042803	molecular_function	protein homodimerization activity
c	0043495	molecular_function	protein-membrane adaptor activity
c	0046982	molecular_function	protein heterodimerization activity
c	0051219	molecular_function	phosphoprotein binding
c	0061462	biological_process	protein localization to lysosome
c	0071230	biological_process	cellular response to amino acid stimulus
c	0072657	biological_process	protein localization to membrane
c	1904263	biological_process	positive regulation of TORC1 signaling
c	1990130	cellular_component	GATOR1 complex
c	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
c	1990877	cellular_component	FNIP-folliculin RagC/D GAP
d	0000287	molecular_function	magnesium ion binding
d	0003924	molecular_function	GTPase activity
d	0005515	molecular_function	protein binding
d	0005525	molecular_function	GTP binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005764	cellular_component	lysosome
d	0005765	cellular_component	lysosomal membrane
d	0005829	cellular_component	cytosol
d	0006351	biological_process	DNA-templated transcription
d	0006915	biological_process	apoptotic process
d	0007264	biological_process	small GTPase-mediated signal transduction
d	0008104	biological_process	protein localization
d	0008380	biological_process	RNA splicing
d	0009267	biological_process	cellular response to starvation
d	0010507	biological_process	negative regulation of autophagy
d	0016020	cellular_component	membrane
d	0016787	molecular_function	hydrolase activity
d	0019003	molecular_function	GDP binding
d	0031669	biological_process	cellular response to nutrient levels
d	0032006	biological_process	regulation of TOR signaling
d	0034198	biological_process	cellular response to amino acid starvation
d	0043200	biological_process	response to amino acid
d	0043231	cellular_component	intracellular membrane-bounded organelle
d	0043495	molecular_function	protein-membrane adaptor activity
d	0046982	molecular_function	protein heterodimerization activity
d	0051020	molecular_function	GTPase binding
d	0060090	molecular_function	molecular adaptor activity
d	0061462	biological_process	protein localization to lysosome
d	0071230	biological_process	cellular response to amino acid stimulus
d	0072657	biological_process	protein localization to membrane
d	0140767	molecular_function	enzyme-substrate adaptor activity
d	1903432	biological_process	regulation of TORC1 signaling
d	1904263	biological_process	positive regulation of TORC1 signaling
d	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
d	1990877	cellular_component	FNIP-folliculin RagC/D GAP
e	0001558	biological_process	regulation of cell growth
e	0001919	biological_process	regulation of receptor recycling
e	0005085	molecular_function	guanyl-nucleotide exchange factor activity
e	0005515	molecular_function	protein binding
e	0005764	cellular_component	lysosome
e	0005765	cellular_component	lysosomal membrane
e	0005768	cellular_component	endosome
e	0005886	cellular_component	plasma membrane
e	0007032	biological_process	endosome organization
e	0007040	biological_process	lysosome organization
e	0008104	biological_process	protein localization
e	0010874	biological_process	regulation of cholesterol efflux
e	0016020	cellular_component	membrane
e	0016197	biological_process	endosomal transport
e	0031669	biological_process	cellular response to nutrient levels
e	0031902	cellular_component	late endosome membrane
e	0032008	biological_process	positive regulation of TOR signaling
e	0032418	biological_process	lysosome localization
e	0035577	cellular_component	azurophil granule membrane
e	0035579	cellular_component	specific granule membrane
e	0038202	biological_process	TORC1 signaling
e	0042632	biological_process	cholesterol homeostasis
e	0043410	biological_process	positive regulation of MAPK cascade
e	0043495	molecular_function	protein-membrane adaptor activity
e	0045121	cellular_component	membrane raft
e	0051020	molecular_function	GTPase binding
e	0060090	molecular_function	molecular adaptor activity
e	0060620	biological_process	regulation of cholesterol import
e	0070062	cellular_component	extracellular exosome
e	0071230	biological_process	cellular response to amino acid stimulus
e	0071986	cellular_component	Ragulator complex
e	0072657	biological_process	protein localization to membrane
e	0101003	cellular_component	ficolin-1-rich granule membrane
e	0150032	biological_process	positive regulation of protein localization to lysosome
e	1904263	biological_process	positive regulation of TORC1 signaling
e	1990877	cellular_component	FNIP-folliculin RagC/D GAP
f	0001558	biological_process	regulation of cell growth
f	0005085	molecular_function	guanyl-nucleotide exchange factor activity
f	0005515	molecular_function	protein binding
f	0005764	cellular_component	lysosome
f	0005765	cellular_component	lysosomal membrane
f	0005768	cellular_component	endosome
f	0005770	cellular_component	late endosome
f	0005886	cellular_component	plasma membrane
f	0008104	biological_process	protein localization
f	0010008	cellular_component	endosome membrane
f	0010761	biological_process	fibroblast migration
f	0016020	cellular_component	membrane
f	0031902	cellular_component	late endosome membrane
f	0032008	biological_process	positive regulation of TOR signaling
f	0035579	cellular_component	specific granule membrane
f	0038202	biological_process	TORC1 signaling
f	0043410	biological_process	positive regulation of MAPK cascade
f	0060090	molecular_function	molecular adaptor activity
f	0070821	cellular_component	tertiary granule membrane
f	0071230	biological_process	cellular response to amino acid stimulus
f	0071986	cellular_component	Ragulator complex
f	0150116	biological_process	regulation of cell-substrate junction organization
f	1902414	biological_process	protein localization to cell junction
f	1904263	biological_process	positive regulation of TORC1 signaling
f	1990877	cellular_component	FNIP-folliculin RagC/D GAP
g	0005085	molecular_function	guanyl-nucleotide exchange factor activity
g	0005515	molecular_function	protein binding
g	0005765	cellular_component	lysosomal membrane
g	0005768	cellular_component	endosome
g	0005770	cellular_component	late endosome
g	0005886	cellular_component	plasma membrane
g	0005925	cellular_component	focal adhesion
g	0008104	biological_process	protein localization
g	0010008	cellular_component	endosome membrane
g	0016020	cellular_component	membrane
g	0019209	molecular_function	kinase activator activity
g	0031902	cellular_component	late endosome membrane
g	0032006	biological_process	regulation of TOR signaling
g	0032008	biological_process	positive regulation of TOR signaling
g	0035579	cellular_component	specific granule membrane
g	0038202	biological_process	TORC1 signaling
g	0043410	biological_process	positive regulation of MAPK cascade
g	0060090	molecular_function	molecular adaptor activity
g	0070062	cellular_component	extracellular exosome
g	0070821	cellular_component	tertiary granule membrane
g	0071230	biological_process	cellular response to amino acid stimulus
g	0071986	cellular_component	Ragulator complex
g	1902414	biological_process	protein localization to cell junction
g	1904263	biological_process	positive regulation of TORC1 signaling
g	1990877	cellular_component	FNIP-folliculin RagC/D GAP
h	0005085	molecular_function	guanyl-nucleotide exchange factor activity
h	0005515	molecular_function	protein binding
h	0005764	cellular_component	lysosome
h	0005765	cellular_component	lysosomal membrane
h	0008361	biological_process	regulation of cell size
h	0031902	cellular_component	late endosome membrane
h	0032008	biological_process	positive regulation of TOR signaling
h	0038202	biological_process	TORC1 signaling
h	0043231	cellular_component	intracellular membrane-bounded organelle
h	0060090	molecular_function	molecular adaptor activity
h	0061462	biological_process	protein localization to lysosome
h	0071230	biological_process	cellular response to amino acid stimulus
h	0071986	cellular_component	Ragulator complex
h	1904263	biological_process	positive regulation of TORC1 signaling
h	1990877	cellular_component	FNIP-folliculin RagC/D GAP
i	0005085	molecular_function	guanyl-nucleotide exchange factor activity
i	0005515	molecular_function	protein binding
i	0005737	cellular_component	cytoplasm
i	0005764	cellular_component	lysosome
i	0005765	cellular_component	lysosomal membrane
i	0005829	cellular_component	cytosol
i	0008361	biological_process	regulation of cell size
i	0009615	biological_process	response to virus
i	0010628	biological_process	positive regulation of gene expression
i	0019079	biological_process	viral genome replication
i	0031902	cellular_component	late endosome membrane
i	0032008	biological_process	positive regulation of TOR signaling
i	0032757	biological_process	positive regulation of interleukin-8 production
i	0032991	cellular_component	protein-containing complex
i	0038202	biological_process	TORC1 signaling
i	0043066	biological_process	negative regulation of apoptotic process
i	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
i	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
i	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
i	0060090	molecular_function	molecular adaptor activity
i	0061462	biological_process	protein localization to lysosome
i	0071230	biological_process	cellular response to amino acid stimulus
i	0071986	cellular_component	Ragulator complex
i	1900182	biological_process	positive regulation of protein localization to nucleus
i	1904263	biological_process	positive regulation of TORC1 signaling
i	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
i	1990877	cellular_component	FNIP-folliculin RagC/D GAP
j	0000785	cellular_component	chromatin
j	0000976	molecular_function	transcription cis-regulatory region binding
j	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
j	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
j	0001892	biological_process	embryonic placenta development
j	0002250	biological_process	adaptive immune response
j	0003677	molecular_function	DNA binding
j	0003700	molecular_function	DNA-binding transcription factor activity
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005737	cellular_component	cytoplasm
j	0005764	cellular_component	lysosome
j	0005765	cellular_component	lysosomal membrane
j	0005829	cellular_component	cytosol
j	0006355	biological_process	regulation of DNA-templated transcription
j	0006357	biological_process	regulation of transcription by RNA polymerase II
j	0006914	biological_process	autophagy
j	0006959	biological_process	humoral immune response
j	0007040	biological_process	lysosome organization
j	0009267	biological_process	cellular response to starvation
j	0010508	biological_process	positive regulation of autophagy
j	0016020	cellular_component	membrane
j	0019899	molecular_function	enzyme binding
j	0032418	biological_process	lysosome localization
j	0034198	biological_process	cellular response to amino acid starvation
j	0045893	biological_process	positive regulation of DNA-templated transcription
j	0045944	biological_process	positive regulation of transcription by RNA polymerase II
j	0046983	molecular_function	protein dimerization activity
j	0061406	biological_process	obsolete positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
j	0140367	biological_process	antibacterial innate immune response
j	1990837	molecular_function	sequence-specific double-stranded DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV

Chain	Residue	Details
d	LYS163-VAL180

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL

Chain	Residue	Details
B	MET100-LEU114

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ

Chain	Residue	Details
A	LEU2186-GLN2200

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN

Chain	Residue	Details
A	SER2323-ASN2343

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by Coxsackievirus B3 protease 3C => ECO:0000269|PubMed:23434374

Chain	Residue	Details
M	GLY17
M	HIS127
V	SER16
V	GLY17
V	HIS127
c	SER16
b	MET1
C	GLN2167
C	LEU2185
C	GLU2190
C	TYR2225
C	GLY2238
C	TRP2239
C	VAL2240
C	THR2245
C	MET2345
C	ILE2356
c	GLY17
c	HIS127
T	GLN60
j	GLN60
i	MET1

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R210

Chain	Residue	Details
X	SER42
X	SER56
X	SER98
X	SER141
e	SER42
e	SER56
e	SER98
e	SER141
T	SER114
j	SER466
j	SER469
T	SER109
T	SER466
T	SER469
j	SER109
j	SER114

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
a	SER67
h	SER67
M	GLY19
M	THR21
M	THR36
M	ILE164
V	GLY19
V	THR21
V	THR36
V	ILE164
c	GLY19
c	THR21
c	THR36
c	ILE164
T	SER122
j	SER122

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:30120233, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
e	CYS3
O	CYS3
O	CYS4
X	CYS3
X	CYS4
e	CYS4
T	SER138
j	SER138

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:30120233, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
H	LYS60
O	LYS20
O	LYS31
O	LYS60
X	LYS20
X	LYS31
X	LYS60
e	LYS20
e	LYS31
e	LYS60
T	SER142
j	SER142

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
T	THR183
H	LYS104
d	SER76
O	LYS103
O	LYS104
X	LYS103
X	LYS104
e	LYS103
e	LYS104
j	THR183

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823

Chain	Residue	Details
j	SER211
N	THR96
N	ASP181
W	THR90
W	THR96
W	ASP181
d	THR90
d	THR96
d	ASP181
G	ASP181
N	THR90
T	SER211

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: S-(2,3-dicarboxypropyl)cysteine => ECO:0000269|PubMed:35662396

Chain	Residue	Details
W	GLU94
d	GLU94
T	CYS212
j	CYS212

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:21617040

Chain	Residue	Details
M	LYS230
M	LYS244
V	LYS142
V	LYS220
V	LYS230
V	LYS244
c	LYS142
c	LYS220
c	LYS230
c	LYS244
W	HIS178
d	HIS178
F	LYS244
M	LYS142
M	LYS220
T	SER332
j	SER332

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:21617040, ECO:0007744|PubMed:23186163

Chain	Residue	Details
W	LYS179
W	ILE220
d	LYS179
d	ILE220
N	LYS179
N	ILE220
T	SER423
j	SER423

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
W	SER219
d	SER219
T	SER441
j	SER441

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
W	SER2
d	SER2
T	SER467
j	SER467

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER15
N	SER15
W	SER15
d	SER15

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99K70

Chain	Residue	Details
W	THR96
d	THR96
G	THR96
N	THR96

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715

Chain	Residue	Details
E	LYS1097
U	LYS1097

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260

Chain	Residue	Details
U	THR700
E	THR700

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303

Chain	Residue	Details
E	LYS932
E	LYS948
U	LYS932
U	LYS948

---