7PQH

Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).

This is a non-PDB format compatible entry.

Summary for 7PQH

• Entry DOI: 10.2210/pdb7pqh/pdb
• EMDB information: 13594 13595
• Descriptor: Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8, Serine/threonine-protein kinase TOR2 (3 entities in total)
• Functional Keywords: target of rapamycin, torc1, kog1, lst8, tor2, frb domain, signaling protein
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Total number of polymer chains: 12
• Total formula weight: 1998351.52

Authors

Felix, J.,Prouteau, M.,Bourgoint, C.,Bonadei, L.,Desfosses, A.,Gabus, C.,Sadian, Y.,Savvides, S.N.,Gutsche, I.,Loewith, R. (deposition date: 2021-09-17, release date: 2023-01-18, Last modification date: 2023-03-29)

• Primary citation: Prouteau, M.,Bourgoint, C.,Felix, J.,Bonadei, L.,Sadian, Y.,Gabus, C.,Savvides, S.N.,Gutsche, I.,Desfosses, A.,Loewith, R.; EGOC inhibits TOROID polymerization by structurally activating TORC1.; Nat.Struct.Mol.Biol., 30:273-285, 2023; PubMed: 36702972; DOI: 10.1038/s41594-022-00912-6

Experimental method

ELECTRON MICROSCOPY (3.87 Å)