8RBX

Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex

This is a non-PDB format compatible entry.

Summary for 8RBX

• Entry DOI: 10.2210/pdb8rbx/pdb
• EMDB information: 19038
• Descriptor: UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, ... (44 entities in total)
• Functional Keywords: integrator complex, pre-termination complex, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 46
• Total formula weight: 2703211.22

Authors

Fianu, I.,Ochmann, M.,Walshe, J.L.,Cramer, P. (deposition date: 2023-12-05, release date: 2024-02-07, Last modification date: 2024-04-10)

• Primary citation: Fianu, I.,Ochmann, M.,Walshe, J.L.,Dybkov, O.,Cruz, J.N.,Urlaub, H.,Cramer, P.; Structural basis of Integrator-dependent RNA polymerase II termination.; Nature, 2024; PubMed: 38570683; DOI: 10.1038/s41586-024-07269-4

Experimental method

ELECTRON MICROSCOPY (4.1 Å)