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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8RBX

Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
11UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNKpolymer8698.91Sus scrofa (pig)
2A, YDNA-directed RNA polymerase subunitpolymer1970217450.12UniProt (A0A7M4DUC2)
Pfam (PF04997)
Pfam (PF05001)
Pfam (PF00623)
Pfam (PF04983)
Pfam (PF05000)
Pfam (PF04998)
Pfam (PF04992)
Pfam (PF04990)
In PDB		Sus scrofa (pig)
3BDNA-directed RNA polymerase subunit betapolymer1174134041.41UniProt (I3LGP4)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF04566)
Pfam (PF04567)
Pfam (PF00562)
Pfam (PF04560)
In PDB		Sus scrofa (pig)
4CDNA-directed RNA polymerase II subunit RPB3polymer27531439.11UniProt (I3LCH3)
Pfam (PF01193)
Pfam (PF01000)
In PDB		Sus scrofa (pig)
5DRNA polymerase II subunit Dpolymer14216331.31UniProt (A0A287ADR4)
Pfam (PF03874)
In PDB		Sus scrofa (pig)
6EDNA-directed RNA polymerase II subunit Epolymer21024644.31UniProt (I3LSI7)
Pfam (PF03871)
Pfam (PF01191)
In PDB		Sus scrofa (pig)RPB5 homolog
7FDNA-directed RNA polymerases I, II, and III subunit RPABC2polymer12714477.01UniProt (A0A8D1KNW4)
In PDB		Sus scrofa (pig)
8GDNA-directed RNA polymerase II subunit RPB7polymer17219314.31UniProt (A0A4X1VKG7)
Pfam (PF03876)
Pfam (PF00575)
In PDB		Sus scrofa (pig)
9HDNA-directed RNA polymerases I, II, and III subunit RPABC3polymer15017162.31UniProt (I3LCB2)
Pfam (PF03870)
In PDB		Sus scrofa (pig)
10IDNA-directed RNA polymerase II subunit RPB9polymer12514541.21UniProt (P60899)
Pfam (PF02150)
Pfam (PF01096)
In PDB		Sus scrofa (pig)RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5
11JDNA-directed RNA polymerases I, II, and III subunit RPABC5polymer677655.11UniProt (A0A4X1VYD0)
Pfam (PF01194)
In PDB		Sus scrofa (pig)
12KDNA-directed RNA polymerase II subunit RPB11-apolymer11713310.31UniProt (F1RKE4)
Pfam (PF13656)
Pfam (PF01193)
In PDB		Sus scrofa (pig)
13LRNA polymerase II subunit Kpolymer587018.21UniProt (A0A8D0JYF1)
In PDB		Sus scrofa (pig)
14M, SHistone H3.3Cpolymer13515350.02UniProt (Q6NXT2)
Pfam (PF00125)
In PDB		Homo sapiens (human)
15Nnon-template DNApolymer14845938.31synthetic construct
16O, UHistone H4polymer10311394.42UniProt (P62805)
Pfam (PF15511)
In PDB		Homo sapiens (human)
17PRNApolymer175549.31synthetic construct
18Q, VHistone H2A type 1polymer13014093.52UniProt (P02262)
Pfam (PF00125)
Pfam (PF16211)
In PDB		Homo sapiens (human)
19R, WHistone H2B type 1-Jpolymer12613981.32UniProt (P06899)
Pfam (PF00125)
In PDB		Homo sapiens (human)
20TTemplate DNApolymer18556757.21synthetic construct
21ZTranscription elongation factor SPT5polymer1087121145.51UniProt (O00267)
Pfam (PF11942)
Pfam (PF03439)
Pfam (PF00467)
In PDB		Homo sapiens (human)hSPT5,DRB sensitivity-inducing factor 160 kDa subunit,DSIF p160,DRB sensitivity-inducing factor large subunit,DSIF large subunit,Tat-cotransactivator 1 protein,Tat-CT1 protein
22aIntegrator complex subunit 1polymer2192244776.11UniProt (Q8N201)
Pfam (PF12432)
In PDB		Homo sapiens (human)
23bIntegrator complex subunit 2polymer1204134451.61UniProt (Q9H0H0)
Pfam (PF14750)
In PDB		Homo sapiens (human)Int2
24dIntegrator complex subunit 4polymer963108306.81UniProt (Q96HW7)
Pfam (PF20168)
Pfam (PF13646)
In PDB		Homo sapiens (human)Int4
25eIntegrator complex subunit 5polymer1021108316.41UniProt (Q6P9B9)
Pfam (PF14837)
Pfam (PF14838)
In PDB		Homo sapiens (human)
26fIntegrator complex subunit 6polymer889100728.31UniProt (Q9UL03)
Pfam (PF13519)
Pfam (PF15300)
In PDB		Homo sapiens (human)
27gIntegrator complex subunit 7polymer964107153.81UniProt (Q9NVH2)
In PDB		Homo sapiens (human)
28hIntegrator complex subunit 8polymer995113219.91UniProt (Q75QN2)
In PDB		Homo sapiens (human)Int8,Protein kaonashi-1
29iIntegrator complex subunit 9polymer65873891.21UniProt (Q9NV88)
Pfam (PF16661)
Pfam (PF10996)
Pfam (PF21382)
In PDB		Homo sapiens (human)Int9,Protein related to CPSF subunits of 74 kDa,RC-74
30jIntegrator complex subunit 10polymer71082339.91UniProt (Q9NVR2)
Pfam (PF21045)
In PDB		Homo sapiens (human)Int10
31kIntegrator complex subunit 11polymer60267956.81UniProt (Q5TA45)
Pfam (PF16661)
Pfam (PF10996)
Pfam (PF07521)
Pfam (PF21386)
In PDB		Homo sapiens (human)
32mIntegrator complex subunit 13polymer70680345.21UniProt (Q9NVM9)
Pfam (PF10221)
In PDB		Homo sapiens (human)Cell cycle regulator Mat89Bb homolog,Germ cell tumor 1,Protein asunder homolog,Sarcoma antigen NY-SAR-95
33nIntegrator complex subunit 14polymer51857526.51UniProt (Q96SY0)
Pfam (PF13519)
Pfam (PF19435)
Pfam (PF20504)
In PDB		Homo sapiens (human)von Willebrand factor A domain-containing protein 9
34oIntegrator complex subunit 15polymer45150303.61UniProt (Q96N11)
Pfam (PF14964)
In PDB		Homo sapiens (human)
35pSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformpolymer59165579.51UniProt (P30153)
Pfam (PF02985)
In PDB		Homo sapiens (human)
36qSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoformpolymer31135836.31UniProt (P67775)
Pfam (PF00149)
In PDB		Homo sapiens (human)
37rDSS1polymer283558.81Trichoplusia ni
38uNegative elongation factor Apolymer52857343.61UniProt (Q9H3P2)
In PDB		Homo sapiens (human)NELF-A,Wolf-Hirschhorn syndrome candidate 2 protein
39vNELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor Bpolymer61368587.71UniProt (Q8WX92)
Pfam (PF06209)
In PDB		Homo sapiens (human)NELF-B,Cofactor of BRCA1
40wNegative elongation factor C/Dpolymer58365748.61UniProt (Q8IXH7)
Pfam (PF04858)
In PDB		Homo sapiens (human)NELF-C/D,TH1-like protein
41xUNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNKpolymer221890.31Homo sapiens (human)
42J, L, k, A, B...ZINC IONnon-polymer65.410Chemie (ZN)
43PMAGNESIUM IONnon-polymer24.31Chemie (MG)
44f, qMANGANESE (II) IONnon-polymer54.92Chemie (MN)
Sequence modifications
A, Y: 1 - 1970 (UniProt: A0A7M4DUC2)
PDBExternal DatabaseDetails
-Tyr 1636deletion
-Ser 1637deletion
-Pro 1638deletion
-Thr 1639deletion
-Ser 1640deletion
-Pro 1641deletion
-Ser 1642deletion
-Tyr 1643deletion
-Ser 1644deletion
-Pro 1645deletion
-Thr 1646deletion
-Ser 1647deletion
-Pro 1648deletion
-Ser 1649deletion
M, S: 1 - 135 (UniProt: Q6NXT2)
PDBExternal DatabaseDetails
Lys 79Asn 79conflict
Ser 87Ala 87conflict
Met 90Gly 90conflict
Q, V: 0 - 129 (UniProt: P02262)
PDBExternal DatabaseDetails
Val 87Ile 88engineered mutation
R, W: -3 - 122 (UniProt: P06899)
PDBExternal DatabaseDetails
Ser 1Ala 5conflict
Ile 15Val 19conflict
Ser 121Ala 125conflict
a: 1 - 2190 (UniProt: Q8N201)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
e: 1 - 1019 (UniProt: Q6P9B9)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
f: 1 - 887 (UniProt: Q9UL03)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
g: 1 - 962 (UniProt: Q9NVH2)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
k: 1 - 600 (UniProt: Q5TA45)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Gln 203Glu 203engineered mutation
o: 1 - 449 (UniProt: Q96N11)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
p: 1 - 589 (UniProt: P30153)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
q: 1 - 309 (UniProt: P67775)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Asn 88Asp 88engineered mutation
v: 4 - 36 (PDB: 8RBX)
v: 36 - 580 (UniProt: Q8WX92)
w: 10 - 590 (UniProt: Q8IXH7)
PDBExternal DatabaseDetails
Ser 8-expression tag
Asn 9-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains46
Total formula weight2702422.9
Non-Polymers*Number of molecules13
Total formula weight788.3
All*Total formula weight2703211.2
*Water molecules are not included.

219869

PDB entries from 2024-05-15

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