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2OQP
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2oqp
SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-21
Descriptor:Interleukin-21
Authors:Bondensgaard, K., Breinholt, J.
Deposit date:2007-02-01
Release date:2007-06-19
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue.
J.Biol.Chem., 282, 2007
2Z3Q
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2z3q
CRYSTAL STRUCTURE OF THE IL-15/IL-15RA COMPLEX
Descriptor:Interleukin-15, Interleukin-15 receptor alpha chain
Authors:Chirifu, M., Yamagata, Y., Davis, S.J., Ikemizu, S.
Deposit date:2007-06-05
Release date:2007-09-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
Nat.Immunol., 8, 2007
2Z3R
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2z3r
CRYSTAL STRUCTURE OF THE IL-15/IL-15RA COMPLEX
Descriptor:Interleukin-15, Interleukin-15 receptor alpha chain
Authors:Chirifu, M., Yamagata, Y., Davis, S.J., Ikemizu, S.
Deposit date:2007-06-05
Release date:2007-09-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
Nat.Immunol., 8, 2007
3TGX
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3tgx
IL-21:IL21R COMPLEX
Descriptor:Interleukin-21 receptor
Authors:Hamming, O.J., Kang, L., Svenson, A., Karlsen, J.L., Rahbek-Nielsen, H., Paludan, S.R., Hjort, S.A., Bondensgaard, K., Hartmann, R.
Deposit date:2011-08-18
Release date:2012-02-15
Modification date:2013-02-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of the interleukin 21 receptor bound to interleukin 21 reveals that a sugar chain interacting with the WSXWS motif is an integral part of the interleukin 21 receptor.
J.Biol.Chem., 2012
2PSM
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2psm
CRYSTAL STRUCTURE OF INTERLEUKIN 15 IN COMPLEX WITH INTERLEUKIN 15 RECEPTOR ALPHA
Descriptor:Interleukin-15, Interleukin-15 receptor alpha chain
Authors:Olsen, S.K., Murayama, K., Kishishita, S., Kukimoto-Niino, M., Terada, T., Shirouzu, M., Ota, N., Kanagawa, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-07
Release date:2007-11-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Crystal Structure of the Interleukin-15{middle dot}Interleukin-15 Receptor {alpha} Complex: INSIGHTS INTO TRANS AND CIS PRESENTATION
J.Biol.Chem., 282, 2007
2XQB
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2xqb
CRYSTAL STRUCTURE OF ANTI-IL-15 ANTIBODY IN COMPLEX WITH HUMAN IL-15
Descriptor:INTERLEUKIN 15, ANTI-IL-15 ANTIBODY
Authors:Lowe, D.C., Gerhardt, S., Ward, A., Hargreaves, D., Anderson, M., Stgallay, S., Vousden, K., Ferraro, F., Pauptit, R.A., Cochrane, D., Pattison, D.V., Buchanan, C., Popovic, B., Finch, D.K., Wilkinson, T., Sleeman, M., Vaughan, T.J., Cruwys, S., Mallinder, P.R.
Deposit date:2010-09-01
Release date:2010-12-29
Modification date:2011-04-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering a High Affinity Anti-Il-15 Antibody: Crystal Structure Reveals an Alpha-Helix in Vh Cdr3 as Key Component of Paratope.
J.Mol.Biol., 406, 2011
4GS7
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4gs7
STRUCTURE OF THE INTERLEUKIN-15 QUATERNARY COMPLEX
Descriptor:Interleukin-15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, Interleukin-15 receptor subunit alpha
Authors:Ring, A.M., Ozkan, E., Feng, D., Garcia, K.C.
Deposit date:2012-08-27
Release date:2012-11-07
Modification date:2012-12-05
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Nat.Immunol., 13, 2012
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