2PSM

Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha

Summary for 2PSM

• Entry DOI: 10.2210/pdb2psm/pdb
• Descriptor: Interleukin-15, Interleukin-15 receptor alpha chain, BENZAMIDINE, ... (4 entities in total)
• Functional Keywords: cytokine, glycoprotein, secreted, alternative splicing, endoplasmic reticulum, golgi apparatus, membrane, nucleus, phosphorylation, receptor, sushi, transmembrane, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• Biological source: Mus musculus (house mouse); More
• Cellular location: Secreted: P48346; Membrane; Single-pass type I membrane protein. Isoform 1: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 3: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 4: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space (By similarity): Q60819
• Total number of polymer chains: 4
• Total formula weight: 44439.90

Authors

Olsen, S.K.,Murayama, K.,Kishishita, S.,Kukimoto-Niino, M.,Terada, T.,Shirouzu, M.,Ota, N.,Kanagawa, O.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-05-07, release date: 2007-11-06, Last modification date: 2021-08-18)

• Primary citation: Olsen, S.K.,Ota, N.,Kishishita, S.,Kukimoto-Niino, M.,Murayama, K.,Uchiyama, H.,Toyama, M.,Terada, T.,Shirouzu, M.,Kanagawa, O.,Yokoyama, S.; Crystal Structure of the Interleukin-15{middle dot}Interleukin-15 Receptor {alpha} Complex: INSIGHTS INTO TRANS AND CIS PRESENTATION; J.Biol.Chem., 282:37191-37204, 2007; PubMed: 17947230; DOI: 10.1074/jbc.M706150200

Experimental method

X-RAY DIFFRACTION (2.19 Å)