2XQB

Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15

Summary for 2XQB

Entry DOI	10.2210/pdb2xqb/pdb
Descriptor	INTERLEUKIN 15, ANTI-IL-15 ANTIBODY, SULFATE ION, ... (5 entities in total)
Functional Keywords	immune system, affinity maturation
Biological source	Homo sapiens (HUMAN) More
Cellular location	Isoform IL15-S48AA: Secreted. Isoform IL15-S21AA: Cytoplasm: P40933
Total number of polymer chains	3
Total formula weight	61378.55
Authors	Lowe, D.C.,Gerhardt, S.,Ward, A.,Hargreaves, D.,Anderson, M.,StGallay, S.,Vousden, K.,Ferraro, F.,Pauptit, R.A.,Cochrane, D.,Pattison, D.V.,Buchanan, C.,Popovic, B.,Finch, D.K.,Wilkinson, T.,Sleeman, M.,Vaughan, T.J.,Cruwys, S.,Mallinder, P.R. (deposition date: 2010-09-01, release date: 2010-12-29, Last modification date: 2023-12-20)
Primary citation	Lowe, D.C.,Gerhardt, S.,Ward, A.,Hargreaves, D.,Anderson, M.,Ferraro, F.,Pauptit, R.A.,Pattison, D.V.,Buchanan, C.,Popovic, B.,Finch, D.K.,Wilkinson, T.,Sleeman, M.,Vaughan, T.J.,Mallinder, P.R. Engineering a High Affinity Anti-Il-15 Antibody: Crystal Structure Reveals an Alpha-Helix in Vh Cdr3 as Key Component of Paratope. J.Mol.Biol., 406:160-, 2011 Cited by PubMed: 21167836 DOI: 10.1016/J.JMB.2010.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation