4GS7

Structure of the Interleukin-15 quaternary complex

Summary for 4GS7

• Entry DOI: 10.2210/pdb4gs7/pdb
• Related: 2b5i 2z3q
• Descriptor: Interleukin-15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ... (9 entities in total)
• Functional Keywords: cytokine, cytokine receptor, immunoregulatory, anti-tumor, anti-viral, reductive methylation, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 71795.02

Authors

Ring, A.M.,Ozkan, E.,Feng, D.,Garcia, K.C. (deposition date: 2012-08-27, release date: 2012-11-07, Last modification date: 2020-07-29)

• Primary citation: Ring, A.M.,Lin, J.X.,Feng, D.,Mitra, S.,Rickert, M.,Bowman, G.R.,Pande, V.S.,Li, P.,Moraga, I.,Spolski, R.,Ozkan, E.,Leonard, W.J.,Garcia, K.C.; Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.; Nat.Immunol., 13:1187-1195, 2012; PubMed: 23104097; DOI: 10.1038/ni.2449

Experimental method

X-RAY DIFFRACTION (2.35 Å)