1YCR
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MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53
Descriptor:MDM2, P53
Authors:Kussie, P.H., Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1RV1
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CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Lukacs, C., Kammlott, U., Graves, B.
Deposit date:2003-12-12
Release date:2004-01-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303, 2004
1V31
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SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G14170 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL11-05-P19
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-21
Release date:2004-04-21
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana
To be Published
1V32
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SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G08430 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL09-47-K03
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-24
Release date:2004-04-24
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
To be Published
1UHR
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SOLUTION STRUCTURE OF THE SWIB DOMAIN OF MOUSE BRG1-ASSOCIATED FACTOR 60A
Descriptor:SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1
Authors:Yamada, K., Saito, K., Nameki, N., Inoue, M., Koshiba, S., Shirouzu, M., Terada, T., Yabuki, T., Aoki, M., Matsuda, T., Seki, E., Hirota, H., Yoshida, M., Tanaka, A., Osanai, T., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-07-09
Release date:2004-08-24
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB domain of mouse BRG1-associated factor 60a
To be Published
1T4E
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STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A BENZODIAZEPINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Modification date:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1T4F
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STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH AN OPTIMIZED P53 PEPTIDE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), optimized p53 peptide
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1Z1M
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NMR STRUCTURE OF UNLIGANDED MDM2
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Uhrinova, S., Uhrin, D., Powers, H., Watt, K., Zheleva, D., Fischer, P., McInnes, C., Barlow, P.N.
Deposit date:2005-03-04
Release date:2005-06-28
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding
J.Mol.Biol., 350, 2005
2AXI
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HDM2 IN COMPLEX WITH A BETA-HAIRPIN
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), cyclic 8-mer peptide
Authors:Mittl, P.R.E., Fasan, R., Robinson, J., Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
2GV2
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MDM2 IN COMPLEX WITH AN 8-MER P53 PEPTIDE ANALOGUE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Schubert, C., Sakurai, K.
Deposit date:2006-05-02
Release date:2006-09-05
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
J.Am.Chem.Soc., 128, 2006
2Z5S
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MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
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MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
3DAB
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STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
3DAC
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STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
2VYR
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STRUCTURE OF HUMAN MDM4 N-TERMINAL DOMAIN BOUND TO A SINGLE DOMAIN ANTIBODY
Descriptor:MDM4 PROTEIN, HUMAN SINGLE DOMAIN ANTIBODY
Authors:Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R.
Deposit date:2008-07-28
Release date:2008-11-25
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody.
J.Mol.Biol., 385, 2009
3FDO
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STRUCTURE OF HUMAN MDMX IN COMPLEX WITH HIGH AFFINITY PEPTIDE
Descriptor:Protein Mdm4, Synthetic high affinity peptide
Authors:Czarna, A.L., Popowicz, G.M., Holak, T.A.
Deposit date:2008-11-26
Release date:2008-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3FE7
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CRYSTAL STRUCTURE OF HDMX BOUND TO THE P53-PEPTIDOMIMETIC AC-PHE-MET-AIB-PMP-TRP-GLU-AC3C-LEU-NH2 AT 1.35A
Descriptor:Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Modification date:2009-04-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3FEA
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CRYSTAL STRUCTURE OF HDMX BOUND TO THE P53-PEPTIDOMIMETIC AC-PHE-MET-AIB-PMP-6-CL-TRP-GLU-AC3C-LEU-NH2 AT 1.33A
Descriptor:Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Modification date:2009-04-07
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3EQS
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CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
Authors:Pazgier, M., Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EQY
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CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Descriptor:Mdm4 protein
Authors:Pazgier, M., Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Modification date:2014-04-02
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3G03
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STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH HIGH AFFINITY PEPTIDE
Descriptor:E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
Authors:Czarna, A.L., Popowicz, G.M., Holak, T.A.
Deposit date:2009-01-27
Release date:2009-04-14
Modification date:2009-04-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3IUX
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CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A POTENT MINIATURE PROTEIN INHIBITOR (18-RESIDUES)
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), p53 binding domain
Authors:Pazgier, M., Lu, W.
Deposit date:2009-08-31
Release date:2009-10-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Apamin as a template for structure-based rational design of potent peptide activators of p53.
Angew.Chem.Int.Ed.Engl., 48, 2009
3JZO
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HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE (PDI)
Descriptor:Protein Mdm4, pDI peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-23
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZP
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HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDI6W)
Descriptor:Protein Mdm4, pDI6W peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZQ
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HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDIQ)
Descriptor:Protein Mdm4, pDIQ peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Modification date:2010-01-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
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